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National Cancer Institute Thesaurus
| Preferred Name | Limonene, (+/-)- | |
| Synonyms |
Limonene, (+/-)- DL-Limonene (+/-)-1-methyl-4-(1-methylethenyl)cyclohexene 1-methyl-4-(1-methylethenyl)cyclohexene LIMONENE, (+/-)- 1-methyl-4-prop-1-en-2-yl-cyclohexene Cajeputene Cinene Dipentene Eulimen Limonene Nesol |
|
| Definitions |
A racemic mixture of limonene, a natural cyclic monoterpene and major component of the oil extracted from citrus rind with chemo-preventive and antitumor activities. The metabolites of DL-limonene, perillic acid, dihydroperillic acid, uroterpenol and limonene 1,2-diol are suggested to inhibit tumor growth through inhibition of p21-dependent signaling, induce apoptosis via the induction of the transforming growth factor beta-signaling pathway, inhibit post-translational modification of signal transduction proteins, result in G1 cell cycle arrest as well as cause differential expression of cell cycle- and apoptosis-related genes. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61709 |
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| CAS_Registry |
138-86-3
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|
| CHEBI_ID |
CHEBI:15384
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|
| Chemical_Formula |
C10H16
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|
| code |
C61709
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|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
FDA GDC
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|
| DEFINITION |
A racemic mixture of limonene, a natural cyclic monoterpene and major component of the oil extracted from citrus rind with chemo-preventive and antitumor activities. The metabolites of DL-limonene, perillic acid, dihydroperillic acid, uroterpenol and limonene 1,2-diol are suggested to inhibit tumor growth through inhibition of p21-dependent signaling, induce apoptosis via the induction of the transforming growth factor beta-signaling pathway, inhibit post-translational modification of signal transduction proteins, result in G1 cell cycle arrest as well as cause differential expression of cell cycle- and apoptosis-related genes.
|
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| FDA_UNII_Code |
9MC3I34447
|
|
| FULL_SYN |
Limonene, (+/-)- DL-Limonene (+/-)-1-methyl-4-(1-methylethenyl)cyclohexene 1-methyl-4-(1-methylethenyl)cyclohexene LIMONENE, (+/-)- 1-methyl-4-prop-1-en-2-yl-cyclohexene Cajeputene Cinene Dipentene Eulimen Limonene Nesol
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| Is_Value_For_GDC_Property | ||
| label |
Limonene, (+/-)-
|
|
| Legacy Concept Name |
DL-Limonene
|
|
| Maps_To |
Limonene, (+/-)-
|
|
| NSC Number |
21446 844
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|
| Preferred_Name |
Limonene, (+/-)-
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|
| prefixIRI |
Thesaurus:C61709
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|
| Semantic_Type |
Pharmacologic Substance
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|
| UMLS_CUI |
C1880232
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| subClassOf |
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