loading...| Preferred Name |
Desonide |
|
| Synonyms |
DESONIDE Desonate Desonide Verdeso |
|
| Definitions |
A synthetic glucocorticosteroid for topical use, with anti-inflammatory activity. Desonide binds to glucocorticoid receptors in the cytoplasm, and the ligand-receptor complex is translocated as a homodimer into the nucleus, where transcription activation via glucocorticoid response elements within glucocorticoid-responsive genes occur. This agent induces transcription of genes coding for anti-inflammatory proteins, including lipocortin-1, interleukin-10, interleukin-1 receptor antagonist and neutral endopeptidase. Increased synthesis of lipocortin-1 has an inhibitory effect on phospholipase A2, which in turn inhibits the release arachidonic acid, thereby controlling the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61702 |
|
| Accepted_Therapeutic_Use_For |
Dermatitis |
|
| CAS_Registry |
638-94-8 |
|
| CHEBI_ID |
CHEBI:204734 |
|
| Chemical_Formula |
C24H32O6 |
|
| code |
C61702 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A synthetic glucocorticosteroid for topical use, with anti-inflammatory activity. Desonide binds to glucocorticoid receptors in the cytoplasm, and the ligand-receptor complex is translocated as a homodimer into the nucleus, where transcription activation via glucocorticoid response elements within glucocorticoid-responsive genes occur. This agent induces transcription of genes coding for anti-inflammatory proteins, including lipocortin-1, interleukin-10, interleukin-1 receptor antagonist and neutral endopeptidase. Increased synthesis of lipocortin-1 has an inhibitory effect on phospholipase A2, which in turn inhibits the release arachidonic acid, thereby controlling the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. |
|
| FDA_UNII_Code |
J280872D1O |
|
| FULL_SYN |
DESONIDE Desonate Desonide Verdeso |
|
| label |
Desonide |
|
| Legacy Concept Name |
Desonide |
|
| Preferred_Name |
Desonide |
|
| prefixIRI |
Thesaurus:C61702 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0011705 |
|
| subClassOf |