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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Cloxacillin | |
| Synonyms |
Cloxacillin CLOXACILLIN |
|
| Definitions |
A semisynthetic beta-lactamase resistant penicillin antibiotic with antibacterial activity. Cloxacillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall, thereby preventing the cross-linkage of peptidoglycans, which are critical components of the bacterial cell wall. This leads to an interruption of the bacterial cell wall and causes bacterial cell lysis. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61688 |
|
| CAS_Registry |
61-72-3
|
|
| CHEBI_ID |
CHEBI:49566
|
|
| Chemical_Formula |
C19H18ClN3O5S
|
|
| code |
C61688
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA
|
|
| DEFINITION |
A semisynthetic beta-lactamase resistant penicillin antibiotic with antibacterial activity. Cloxacillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall, thereby preventing the cross-linkage of peptidoglycans, which are critical components of the bacterial cell wall. This leads to an interruption of the bacterial cell wall and causes bacterial cell lysis.
|
|
| Display_Name |
Cloxacillin
|
|
| FDA_UNII_Code |
O6X5QGC2VB
|
|
| FULL_SYN |
Cloxacillin CLOXACILLIN
|
|
| Has_Salt_Form | ||
| label |
Cloxacillin
|
|
| Legacy Concept Name |
Cloxacillin
|
|
| NCI_Drug_Dictionary_ID |
813342
|
|
| Preferred_Name |
Cloxacillin
|
|
| prefixIRI |
Thesaurus:C61688
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C0009077
|
|
| subClassOf |
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