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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Clemastine | |
| Synonyms |
(+)-(2R)-2-(2-(((R)-p-Chloro-alpha-methyl-alpha-phenylbenzyl)oxy)ethyl)-1-methylpyrrolidine Mecloprodin CLEMASTINE Clemastine HS-592 Meclastin |
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| Definitions |
A synthetic ethanolamine, with anticholinergic, sedative, and histamine H1 antagonistic activities. Upon administration, clemastine blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial and gastrointestinal smooth muscles, including vasodilation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscles. Clemastine also prevents histamine-induced pain and itching of mucous membranes. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61682 |
|
| CAS_Registry |
15686-51-8
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|
| CHEBI_ID |
CHEBI:3738
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|
| Chemical_Formula |
C21H26ClNO
|
|
| code |
C61682
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA HemOnc
|
|
| DEFINITION |
A synthetic ethanolamine, with anticholinergic, sedative, and histamine H1 antagonistic activities. Upon administration, clemastine blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial and gastrointestinal smooth muscles, including vasodilation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscles. Clemastine also prevents histamine-induced pain and itching of mucous membranes.
|
|
| FDA_UNII_Code |
95QN29S1ID
|
|
| FULL_SYN |
(+)-(2R)-2-(2-(((R)-p-Chloro-alpha-methyl-alpha-phenylbenzyl)oxy)ethyl)-1-methylpyrrolidine Mecloprodin CLEMASTINE Clemastine HS-592 Meclastin
|
|
| Has_Salt_Form | ||
| label |
Clemastine
|
|
| Legacy Concept Name |
Clemastine
|
|
| Preferred_Name |
Clemastine
|
|
| prefixIRI |
Thesaurus:C61682
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|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C0008929
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|
| subClassOf |
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