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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Arformoterol | |
| Synonyms |
Arformoterol ARFORMOTEROL |
|
| Definitions |
A long-acting beta-2 adrenergic agonist and isomer of formoterol with bronchodilator activity. Arformoterol selectively binds to and activates beta-2 adrenergic receptors in bronchiolar smooth muscle, thereby causing stimulation of adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased intracellular cAMP levels cause relaxation of bronchial smooth muscle and lead to a reduced release of inflammatory mediators from mast cells. This may eventually lead to an improvement of airway function. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61641 |
|
| CAS_Registry |
67346-49-0
|
|
| CHEBI_ID |
CHEBI:408174
|
|
| Chemical_Formula |
C19H24N2O4
|
|
| code |
C61641
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
|
|
| DEFINITION |
A long-acting beta-2 adrenergic agonist and isomer of formoterol with bronchodilator activity. Arformoterol selectively binds to and activates beta-2 adrenergic receptors in bronchiolar smooth muscle, thereby causing stimulation of adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased intracellular cAMP levels cause relaxation of bronchial smooth muscle and lead to a reduced release of inflammatory mediators from mast cells. This may eventually lead to an improvement of airway function.
|
|
| FDA_UNII_Code |
F91H02EBWT
|
|
| FULL_SYN |
Arformoterol ARFORMOTEROL
|
|
| Has_Salt_Form | ||
| label |
Arformoterol
|
|
| Legacy Concept Name |
Arformoterol
|
|
| Preferred_Name |
Arformoterol
|
|
| prefixIRI |
Thesaurus:C61641
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C0969589
|
|
| subClassOf |
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