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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Clomiphene | |
| Synonyms |
2-[p-(2-Chloro-1,2-diphenylvinyl)phenoxy]triethylamine CLOMIPHENE Clomiphene |
|
| Definitions |
A triphenylethylene nonsteroidal ovulatory stimulant evaluated for antineoplastic activity against breast cancer. Clomiphene has both estrogenic and anti-estrogenic activities that compete with estrogen for binding at estrogen receptor sites in target tissues. This agent causes the release of the pituitary gonadotropins follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to ovulation. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61607 |
|
| CAS_Registry |
911-45-5
|
|
| CHEBI_ID |
CHEBI:3752
|
|
| code |
C61607
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
FDA GDC
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|
| DEFINITION |
A triphenylethylene nonsteroidal ovulatory stimulant evaluated for antineoplastic activity against breast cancer. Clomiphene has both estrogenic and anti-estrogenic activities that compete with estrogen for binding at estrogen receptor sites in target tissues. This agent causes the release of the pituitary gonadotropins follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to ovulation. (NCI04)
|
|
| FDA_UNII_Code |
1HRS458QU2
|
|
| FULL_SYN |
2-[p-(2-Chloro-1,2-diphenylvinyl)phenoxy]triethylamine CLOMIPHENE Clomiphene
|
|
| Has_Salt_Form | ||
| Is_Value_For_GDC_Property | ||
| label |
Clomiphene
|
|
| Legacy Concept Name |
Clomiphene_Base
|
|
| Maps_To |
Clomiphene
|
|
| Preferred_Name |
Clomiphene
|
|
| prefixIRI |
Thesaurus:C61607
|
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
|
|
| UMLS_CUI |
C0009008
|
|
| subClassOf |
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