loading...| Preferred Name |
Pazopanib Hydrochloride |
|
| Synonyms |
5-((4-((2,3-Dimethyl-2h-Indazol-6-Yl)Methylamino)Pyrimidin-2-yl)Amino)-2-Methylbenzenesulfonamide Monohydrochloride Pazopanib Hydrochloride PAZOPANIB HYDROCHLORIDE pazopanib hydrochloride GW786034B Pazopater Votrient |
|
| Definitions |
The hydrochloride salt of a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), which may result in inhibition of angiogenesis in tumors in which these receptors are upregulated. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C60779 |
|
| ALT_DEFINITION |
A drug that is used to treat kidney cancer and is being studied in the treatment of other types of cancer. It may prevent the growth of new blood vessels that tumors need to grow. It is a type of protein tyrosine kinase inhibitor and a type of antiangiogenesis agent. |
|
| CAS_Registry |
635702-64-6 |
|
| Chemical_Formula |
C21H23N7O2S.HCl |
|
| code |
C60779 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC |
|
| DEFINITION |
The hydrochloride salt of a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), which may result in inhibition of angiogenesis in tumors in which these receptors are upregulated. |
|
| Display_Name |
Pazopanib Hydrochloride |
|
| FDA_UNII_Code |
33Y9ANM545 |
|
| FULL_SYN |
5-((4-((2,3-Dimethyl-2h-Indazol-6-Yl)Methylamino)Pyrimidin-2-yl)Amino)-2-Methylbenzenesulfonamide Monohydrochloride Pazopanib Hydrochloride PAZOPANIB HYDROCHLORIDE pazopanib hydrochloride GW786034B Pazopater Votrient |
|
| Has_Free_Acid_Or_Base_Form | ||
| Has_Target |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17328 |
|
| Is_Value_For_GDC_Property | ||
| label |
Pazopanib Hydrochloride |
|
| Legacy Concept Name |
Pazopanib |
|
| Maps_To |
Pazopanib Hydrochloride |
|
| NCI_Drug_Dictionary_ID |
476479 |
|
| NSC Number |
737754 |
|
| PDQ_Closed_Trial_Search_ID |
476479 |
|
| PDQ_Open_Trial_Search_ID |
476479 |
|
| Preferred_Name |
Pazopanib Hydrochloride |
|
| prefixIRI |
Thesaurus:C60779 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C1872226 |
|
| subClassOf |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C159199 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C159198 |