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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Isosorbide | |
| Synonyms |
ISOSORBIDE Ismotic Isosorbide |
|
| Definitions |
An organic nitrate with vasodilator activity. Isosorbide relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle. Elevated cGMP levels in smooth muscle activate cGMP-dependent kinase activity that leads to release of sequestered Ca2+. In turn, free Ca+ triggers dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition isosorbide relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C60773 |
|
| CAS_Registry |
652-67-5
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|
| Chemical_Formula |
C6H10O4
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|
| code |
C60773
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
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|
| DEFINITION |
An organic nitrate with vasodilator activity. Isosorbide relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle. Elevated cGMP levels in smooth muscle activate cGMP-dependent kinase activity that leads to release of sequestered Ca2+. In turn, free Ca+ triggers dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition isosorbide relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area.
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| FDA_UNII_Code |
WXR179L51S
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|
| FULL_SYN |
ISOSORBIDE Ismotic Isosorbide
|
|
| Has_Salt_Form | ||
| Has_Target | ||
| label |
Isosorbide
|
|
| Legacy Concept Name |
Isosorbide
|
|
| NSC Number |
40725
|
|
| Preferred_Name |
Isosorbide
|
|
| prefixIRI |
Thesaurus:C60773
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|
| Semantic_Type |
Pharmacologic Substance
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|
| UMLS_CUI |
C0022251
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| subClassOf |
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