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National Cancer Institute Thesaurus
| Preferred Name | Ketoconazole | |
| Synonyms |
Ketoconazole Cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine Orifungal M ketoconazole KETOCONAZOLE Fungarest Fungoral Ketoderm Ketoisdin Nizoral Panfungol R-41400 Xolegel |
|
| Definitions |
A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C605 |
|
| Accepted_Therapeutic_Use_For |
Seborrheic Dermatitis; Prostate cancer
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|
| ALT_DEFINITION |
A drug that treats infection caused by a fungus. It is also used as a treatment for prostate cancer because it can block the production of male sex hormones.
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|
| CAS_Registry |
65277-42-1
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|
| CHEBI_ID |
CHEBI:47519
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|
| Chemical_Formula |
C26H28Cl2N4O4
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|
| code |
C605
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|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192234 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc OORO
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|
| DEFINITION |
A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. (NCI04)
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|
| Display_Name |
Ketoconazole
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|
| FDA_UNII_Code |
R9400W927I
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|
| FULL_SYN |
Ketoconazole Cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine Orifungal M ketoconazole KETOCONAZOLE Fungarest Fungoral Ketoderm Ketoisdin Nizoral Panfungol R-41400 Xolegel
|
|
| Is_Value_For_GDC_Property | ||
| label |
Ketoconazole
|
|
| Legacy Concept Name |
Ketoconazole
|
|
| Maps_To |
Ketoconazole
|
|
| NCI_Drug_Dictionary_ID |
39488
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|
| NSC Number |
317629
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|
| PDQ_Closed_Trial_Search_ID |
39488
|
|
| PDQ_Open_Trial_Search_ID |
39488
|
|
| Preferred_Name |
Ketoconazole
|
|
| prefixIRI |
Thesaurus:C605
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|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
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|
| UMLS_CUI |
C0022625
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| subClassOf |
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