National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Recombinant Interferon
Synonyms

Interferons

Human lymphoblastoid interferon

Recombinant Interferon

Human Lymphoblastoid Interferon

Human Leukocyte Interferon

IFN
Definitions

One of a group of recombinant therapeutic glycoprotein cytokines with antiviral, anti-proliferative, and immunomodulating activities. Interferons bind to specific cell-surface receptors, leading to the transcription and translation of genes with interferon-specific response elements (ISREs). The resultant proteins mediate many complex effects, ultimately leading to inhibition of viral protein synthesis and cellular growth, alteration of cellular differentiation, interference with oncogene expression, activation of natural killer cells, alteration of cell surface antigen expression, and augmentation of lymphocyte and macrophage cytotoxicity. The production of endogenous interferons is induced in response to foreign agents such as bacteria, viruses and parasites and to tumor cells.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C584
CAS_Registry

9008-1-11
code

C584
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537
Contributing_Source

GDC
DEFINITION

One of a group of recombinant therapeutic glycoprotein cytokines with antiviral, anti-proliferative, and immunomodulating activities. Interferons bind to specific cell-surface receptors, leading to the transcription and translation of genes with interferon-specific response elements (ISREs). The resultant proteins mediate many complex effects, ultimately leading to inhibition of viral protein synthesis and cellular growth, alteration of cellular differentiation, interference with oncogene expression, activation of natural killer cells, alteration of cell surface antigen expression, and augmentation of lymphocyte and macrophage cytotoxicity. The production of endogenous interferons is induced in response to foreign agents such as bacteria, viruses and parasites and to tumor cells.
FULL_SYN

Interferons

Human lymphoblastoid interferon

Recombinant Interferon

Human Lymphoblastoid Interferon

Human Leukocyte Interferon

IFN
Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909
label

Recombinant Interferon
Legacy Concept Name

Therapeutic_Interferon
Maps_To

Recombinant Interferon
NCI_Drug_Dictionary_ID

40863
PDQ_Closed_Trial_Search_ID

40863
PDQ_Open_Trial_Search_ID

40863
Preferred_Name

Recombinant Interferon
prefixIRI

Thesaurus:C584
Semantic_Type

Amino Acid, Peptide, or Protein

Pharmacologic Substance
UMLS_CUI

C1522537
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1283
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