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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Hydroxamic Acids | |
| Synonyms |
Hydroxamic Acids |
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| Definitions |
A group of weak acids with the general chemical formula RC(=O)N(R')OH and antineoplastic and antimicrobial activities. Hydroxamic acids covalently bind to the zinc(II) ion in the active sites of matrix metalloproteinases (MMP), thereby inhibiting the action of MMPs, inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. (NCI04) |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C556 |
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| CHEBI_ID |
CHEBI:24650
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| code |
C556
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| DEFINITION |
A group of weak acids with the general chemical formula RC(=O)N(R')OH and antineoplastic and antimicrobial activities. Hydroxamic acids covalently bind to the zinc(II) ion in the active sites of matrix metalloproteinases (MMP), thereby inhibiting the action of MMPs, inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. (NCI04)
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| FULL_SYN |
Hydroxamic Acids
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| label |
Hydroxamic Acids
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| Legacy Concept Name |
Hydroxamic_Acids
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| Preferred_Name |
Hydroxamic Acids
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| prefixIRI |
Thesaurus:C556
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0020314
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| subClassOf |
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