loading...| Preferred Name | Gossypol | |
| Synonyms |
(2,2'-Binaphthalene)-8,8'-dicarboxaldehyde, 1,1',6,6'7, 7'-hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl- 2,2'-bis(1,6,7-trihydroxy-4-methyl-5-isopropyl-8-aldehydonaphthalene) 2,2'-bis[8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene] Cottonseed Meal Toxin cottonseed meal toxin (+/-)-Gossypol 1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)[2,2'-binaphthalene]-8,8'-dicarboxaldehyde 1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3-3'-dimethyl[2,2'-binaphthalene]-8,8'-dicarboxaldehyde BL-193 GOSSYPOL Gossypol No Fertil Pogosin Tash 1 gossypol |
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| Definitions |
An orally-active polyphenolic aldehyde with potential antineoplastic activity. Derived primarily from unrefined cottonseed oil, gossypol induces cell cycle arrest at the G0/G1 phase, thereby inhibiting DNA replication and inducing apoptosis. This agent also inhibits cell-signaling enzymes, resulting in inhibition of cell growth, and may act as a male contraceptive. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C529 |
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| ALT_DEFINITION |
A substance being studied in the treatment of several types of cancer. It comes from the seed of the cotton plant (Gossypium). It blocks the growth of cells and may kill cancer cells. Cottonseed meal toxin may also act as a male contraceptive (a type of birth control). |
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| CAS_Registry |
303-45-7 |
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| CHEBI_ID |
CHEBI:28584 |
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| Chemical_Formula |
C30H30O8 |
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| code |
C529 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
FDA GDC |
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| DEFINITION |
An orally-active polyphenolic aldehyde with potential antineoplastic activity. Derived primarily from unrefined cottonseed oil, gossypol induces cell cycle arrest at the G0/G1 phase, thereby inhibiting DNA replication and inducing apoptosis. This agent also inhibits cell-signaling enzymes, resulting in inhibition of cell growth, and may act as a male contraceptive. |
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| FDA_UNII_Code |
KAV15B369O |
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| FULL_SYN |
(2,2'-Binaphthalene)-8,8'-dicarboxaldehyde, 1,1',6,6'7, 7'-hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl- 2,2'-bis(1,6,7-trihydroxy-4-methyl-5-isopropyl-8-aldehydonaphthalene) 2,2'-bis[8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene] Cottonseed Meal Toxin cottonseed meal toxin (+/-)-Gossypol 1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)[2,2'-binaphthalene]-8,8'-dicarboxaldehyde 1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3-3'-dimethyl[2,2'-binaphthalene]-8,8'-dicarboxaldehyde BL-193 GOSSYPOL Gossypol No Fertil Pogosin Tash 1 gossypol |
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| Has_Salt_Form | ||
| Is_Value_For_GDC_Property | ||
| label |
Gossypol |
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| Legacy Concept Name |
Gossypol |
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| Maps_To |
Gossypol |
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| NCI_Drug_Dictionary_ID |
505287 |
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| NSC Number |
56817 624336 |
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| PDQ_Closed_Trial_Search_ID |
505287 |
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| PDQ_Open_Trial_Search_ID |
505287 |
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| Preferred_Name |
Gossypol |
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| prefixIRI |
Thesaurus:C529 |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0018096 |
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| subClassOf |