National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Cabozantinib
Synonyms

CABOZANTINIB

Cabozantinib

N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1- dicarboxamide

1,1-Cyclopropanedicarboxamide, N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4- fluorophenyl)-

Definitions

An orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Cabozantinib strongly binds to and inhibits several RTKs, which are often overexpressed in a variety of cancer cell types, including hepatocyte growth factor receptor (MET), RET (rearranged during transfection), vascular endothelial growth factor receptor types 1 (VEGFR-1), 2 (VEGFR-2), and 3 (VEGFR-3), mast/stem cell growth factor (KIT), FMS-like tyrosine kinase 3 (FLT-3), TIE-2 (TEK tyrosine kinase, endothelial), tropomyosin-related kinase B (TRKB) and AXL. This may result in an inhibition of both tumor growth and angiogenesis, and eventually lead to tumor regression.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52200

CAS_Registry

849217-68-1

Chemical_Formula

C28H24FN3O5

code

C52200

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C179531

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C179478

Contributing_Source

CTRP

FDA

GDC

HemOnc

PCDC

DEFINITION

An orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Cabozantinib strongly binds to and inhibits several RTKs, which are often overexpressed in a variety of cancer cell types, including hepatocyte growth factor receptor (MET), RET (rearranged during transfection), vascular endothelial growth factor receptor types 1 (VEGFR-1), 2 (VEGFR-2), and 3 (VEGFR-3), mast/stem cell growth factor (KIT), FMS-like tyrosine kinase 3 (FLT-3), TIE-2 (TEK tyrosine kinase, endothelial), tropomyosin-related kinase B (TRKB) and AXL. This may result in an inhibition of both tumor growth and angiogenesis, and eventually lead to tumor regression.

Display_Name

Cabozantinib

FDA_UNII_Code

1C39JW444G

FULL_SYN

CABOZANTINIB

Cabozantinib

N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1- dicarboxamide

1,1-Cyclopropanedicarboxamide, N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4- fluorophenyl)-

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97938

Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18186

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28496

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17328

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18488

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17475

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26203

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26202

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C33983

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17975

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18539

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Cabozantinib

Legacy Concept Name

XL184

Maps_To

Cabozantinib

Preferred_Name

Cabozantinib

prefixIRI

Thesaurus:C52200

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C3181682

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C93259

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C200418

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C159438

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C143099

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