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National Cancer Institute Thesaurus
| Preferred Name | Recombinant Interferon Beta | |
| Synonyms |
Beta Interferon Interferon-beta INTERFERON BETA Interferon Beta Interferon, Beta Human Interferon Beta Interferon-B Recombinant Interferon Beta Betantrone Feron Naferon |
|
| Definitions |
A recombinant protein which is chemically identical to or similar to endogenous interferon beta with antiviral and anti-tumor activities. Endogenous interferons beta are cytokines produced by nucleated cells (predominantly natural killer cells) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes with an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral (the most important being inhibition of viral protein synthesis), antiproliferative and immune modulating effects. The recombinant therapeutic forms of interferon beta are interferon beta 1-a and interferon beta 1-b. (NCI05) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C495 |
|
| Accepted_Therapeutic_Use_For |
multiple sclerosis
|
|
| CAS_Registry |
77238-31-4
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|
| code |
C495
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC
|
|
| DEFINITION |
A recombinant protein which is chemically identical to or similar to endogenous interferon beta with antiviral and anti-tumor activities. Endogenous interferons beta are cytokines produced by nucleated cells (predominantly natural killer cells) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes with an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral (the most important being inhibition of viral protein synthesis), antiproliferative and immune modulating effects. The recombinant therapeutic forms of interferon beta are interferon beta 1-a and interferon beta 1-b. (NCI05)
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|
| Display_Name |
Recombinant Interferon Beta
|
|
| FDA_UNII_Code |
V9GU1EM8SF
|
|
| FULL_SYN |
Beta Interferon Interferon-beta INTERFERON BETA Interferon Beta Interferon, Beta Human Interferon Beta Interferon-B Recombinant Interferon Beta Betantrone Feron Naferon
|
|
| Is_Related_To_Endogenous_Product | ||
| Is_Value_For_GDC_Property | ||
| label |
Recombinant Interferon Beta
|
|
| Legacy Concept Name |
Therapeutic_Interferon_Beta
|
|
| Maps_To |
Recombinant Interferon Beta
|
|
| NCI_Drug_Dictionary_ID |
40468
|
|
| NSC Number |
373361 658933
|
|
| PDQ_Closed_Trial_Search_ID |
40468
|
|
| PDQ_Open_Trial_Search_ID |
40468
|
|
| Preferred_Name |
Recombinant Interferon Beta
|
|
| prefixIRI |
Thesaurus:C495
|
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance
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|
| UMLS_CUI |
C0015980
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|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |
| Mapping To | Ontology | Source |
|---|---|---|
| http://purl.bioontology.org/ontology/PDQ/CDR0000040468 | PDQ | LOOM |
| http://purl.obolibrary.org/obo/NCIT_C495 | BERO | LOOM |