loading...| Preferred Name | Aprepitant | |
| Synonyms |
5-(((2R,3S)-2-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)-4-morpholinyl)methyl)-1,2-dihydro-3H-1,2,4-Triazol-3-one APREPITANT Aprepitant CINVANTI Emend L-754030 MK-0869 ONO-7436 aprepitant |
|
| Definitions |
A small molecule, high-affinity substance P antagonist (SPA) with antiemetic activity. Crossing the blood brain barrier, aprepitant binds selectively to the human substance P/neurokinin 1 receptor in the central nervous system (CNS), thereby inhibiting receptor binding of endogenous substance P and substance P-induced emesis. This agent has little or no affinity for serotonin type 3 (5-HT3), dopamine, and corticosteroid receptors. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49173 |
|
| ALT_DEFINITION |
A drug used together with other drugs to prevent and control the nausea and vomiting caused by cancer treatment. It is also used to treat nausea and vomiting after surgery. It is a type of antiemetic and a type of substance P/neurokinin 1 receptor antagonist. |
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| CAS_Registry |
170729-80-3 |
|
| CHEBI_ID |
CHEBI:499361 |
|
| Chemical_Formula |
C23H21F7N4O3 |
|
| code |
C49173 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 |
|
| Contributing_Source |
CTRP FDA HemOnc |
|
| DEFINITION |
A small molecule, high-affinity substance P antagonist (SPA) with antiemetic activity. Crossing the blood brain barrier, aprepitant binds selectively to the human substance P/neurokinin 1 receptor in the central nervous system (CNS), thereby inhibiting receptor binding of endogenous substance P and substance P-induced emesis. This agent has little or no affinity for serotonin type 3 (5-HT3), dopamine, and corticosteroid receptors. |
|
| Display_Name |
Aprepitant |
|
| FDA_UNII_Code |
1NF15YR6UY |
|
| FULL_SYN |
5-(((2R,3S)-2-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)-4-morpholinyl)methyl)-1,2-dihydro-3H-1,2,4-Triazol-3-one APREPITANT Aprepitant CINVANTI Emend L-754030 MK-0869 ONO-7436 aprepitant |
|
| label |
Aprepitant |
|
| Legacy Concept Name |
Aprepitant |
|
| NCI_Drug_Dictionary_ID |
454517 |
|
| PDQ_Closed_Trial_Search_ID |
454517 |
|
| PDQ_Open_Trial_Search_ID |
454517 |
|
| Preferred_Name |
Aprepitant |
|
| prefixIRI |
Thesaurus:C49173 |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C1176306 |
|
| subClassOf |