loading...| Preferred Name |
Ingenol Mebutate |
|
| Synonyms |
2-Butenoic acid, 2-methyl-, (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a- octahydro-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a- methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl ester, (2Z)- INGENOL MEBUTATE Ingenol Mebutate Ingenol-3-angelate I3A PEP-005 PEP005 |
|
| Definitions |
A selective small-molecule activator of protein kinase C (PKC) isolated from the plant Euphorbia peplus with potential antineoplastic activity. Ingenol mebutate activates various protein kinase C (PKC) isoforms, thereby inducing apoptosis in some tumor cells, including myeloid leukemia cells, melanoma cells, and basal cell carcinoma cells. The PKC family consists of signaling isoenzymes that regulate many cell processes including proliferation, differentiation, and apoptosis. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48398 |
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| CAS_Registry |
75567-37-2 |
|
| Chemical_Formula |
C25H34O6 |
|
| code |
C48398 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
FDA GDC |
|
| DEFINITION |
A selective small-molecule activator of protein kinase C (PKC) isolated from the plant Euphorbia peplus with potential antineoplastic activity. Ingenol mebutate activates various protein kinase C (PKC) isoforms, thereby inducing apoptosis in some tumor cells, including myeloid leukemia cells, melanoma cells, and basal cell carcinoma cells. The PKC family consists of signaling isoenzymes that regulate many cell processes including proliferation, differentiation, and apoptosis. |
|
| FDA_UNII_Code |
7686S50JAH |
|
| FULL_SYN |
2-Butenoic acid, 2-methyl-, (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a- octahydro-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a- methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl ester, (2Z)- INGENOL MEBUTATE Ingenol Mebutate Ingenol-3-angelate I3A PEP-005 PEP005 |
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| Is_Value_For_GDC_Property | ||
| label |
Ingenol Mebutate |
|
| Legacy Concept Name |
Ingenol_3-Angelate |
|
| Maps_To |
Ingenol Mebutate |
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| NCI_Drug_Dictionary_ID |
432941 |
|
| PDQ_Closed_Trial_Search_ID |
432941 |
|
| PDQ_Open_Trial_Search_ID |
432941 |
|
| Preferred_Name |
Ingenol Mebutate |
|
| prefixIRI |
Thesaurus:C48398 |
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| PubMedID_Primary_Reference |
19178487 |
|
| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C1452152 |
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| subClassOf |