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National Cancer Institute Thesaurus
| Preferred Name | Iloprost | |
| Synonyms |
Pentanoic Acid, 5-(hexahydro-5-hydroxy-4-(3-hydroxy-4-methyl-1-octen-6-ynyl)-2(1H)-pentalenylidene)- (E)-(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-((E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-ynyl)-delta(sup 2(1H),delta)-pentalenevaleric Acid Iloprost Clathrate Ciloprost ILOPROST Iloprost Ventavis ZK 36374 iloprost |
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| Definitions |
A prostacyclin analogue with potential chemopreventive activity. Iloprost binds to the prostacyclin receptor in various target cells, thereby causing vasodilation, inhibition of platelet aggregation, and decreased tumor cell adhesion to endothelium among other effects. Prostacyclin is a naturally occurring eicosanoid with anti-inflammatory, antineoplastic, and anti-metastatic properties. (NCI05) |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48397 |
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| ALT_DEFINITION |
A substance that is being studied in the prevention of lung cancer. It belongs to the family of drugs called prostaglandin analogs.
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| CAS_Registry |
78919-13-8
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|
| CHEBI_ID |
CHEBI:63916
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| Chemical_Formula |
C22H32O4
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|
| code |
C48397
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
FDA GDC
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|
| DEFINITION |
A prostacyclin analogue with potential chemopreventive activity. Iloprost binds to the prostacyclin receptor in various target cells, thereby causing vasodilation, inhibition of platelet aggregation, and decreased tumor cell adhesion to endothelium among other effects. Prostacyclin is a naturally occurring eicosanoid with anti-inflammatory, antineoplastic, and anti-metastatic properties. (NCI05)
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| FDA_UNII_Code |
JED5K35YGL
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| FULL_SYN |
Pentanoic Acid, 5-(hexahydro-5-hydroxy-4-(3-hydroxy-4-methyl-1-octen-6-ynyl)-2(1H)-pentalenylidene)- (E)-(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-((E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-ynyl)-delta(sup 2(1H),delta)-pentalenevaleric Acid Iloprost Clathrate Ciloprost ILOPROST Iloprost Ventavis ZK 36374 iloprost
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| Is_Value_For_GDC_Property | ||
| label |
Iloprost
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|
| Legacy Concept Name |
Iloprost
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|
| Maps_To |
Iloprost
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| NCI_Drug_Dictionary_ID |
365679
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| PDQ_Closed_Trial_Search_ID |
365679
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| PDQ_Open_Trial_Search_ID |
365679
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| Preferred_Name |
Iloprost
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| prefixIRI |
Thesaurus:C48397
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0079594
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| subClassOf |
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