loading...| Preferred Name |
Ondansetron Hydrochloride |
|
| Synonyms |
ondansetron hydrochloride ONDANSETRON HYDROCHLORIDE Ondansetron Hydrochloride 4H-Carbazol-4-one, 1,2,3,9-Tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-, Monohydrochloride, (+-)-, Dihydrate GR 38032F GR-C507/75 SN-307 Zofran |
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| Definitions |
The hydrochloride salt of the racemic form of ondansetron, a carbazole derivative and a selective, competitive serotonin 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist with antiemetic activity. Although its mechanism of action has not been fully characterized, ondansetron appears to competitively block the action of serotonin at 5HT3 receptors peripherally in the gastrointestinal tract as well as centrally in the area postrema of the CNS, where the chemoreceptor trigger zone (CTZ) for vomiting is located, resulting in the suppression of chemotherapy- and radiotherapy-induced nausea and vomiting. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48007 |
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| Accepted_Therapeutic_Use_For |
Nausea and vomiting prophylaxis, chemotherapy-induced and postoperative |
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| ALT_DEFINITION |
The active ingredient in a drug used to treat nausea and vomiting caused by cancer treatment. It is a type of serotonin receptor antagonist and a type of antiemetic. |
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| CAS_Registry |
103639-04-9 |
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| Chemical_Formula |
C18H19N3O.HCl.2H2O |
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| code |
C48007 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
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| Contributing_Source |
CTRP FDA GDC |
|
| DEFINITION |
The hydrochloride salt of the racemic form of ondansetron, a carbazole derivative and a selective, competitive serotonin 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist with antiemetic activity. Although its mechanism of action has not been fully characterized, ondansetron appears to competitively block the action of serotonin at 5HT3 receptors peripherally in the gastrointestinal tract as well as centrally in the area postrema of the CNS, where the chemoreceptor trigger zone (CTZ) for vomiting is located, resulting in the suppression of chemotherapy- and radiotherapy-induced nausea and vomiting. |
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| Display_Name |
Ondansetron Hydrochloride |
|
| FDA_UNII_Code |
NMH84OZK2B |
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| FULL_SYN |
ondansetron hydrochloride ONDANSETRON HYDROCHLORIDE Ondansetron Hydrochloride 4H-Carbazol-4-one, 1,2,3,9-Tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-, Monohydrochloride, (+-)-, Dihydrate GR 38032F GR-C507/75 SN-307 Zofran |
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| Has_Free_Acid_Or_Base_Form | ||
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Ondansetron Hydrochloride |
|
| Legacy Concept Name |
Ondansetron_Hydrochloride |
|
| Maps_To |
Ondansetron Hydrochloride |
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| NCI_Drug_Dictionary_ID |
489533 |
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| NSC Number |
665799 |
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| PDQ_Closed_Trial_Search_ID |
489533 |
|
| PDQ_Open_Trial_Search_ID |
489533 |
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| Preferred_Name |
Ondansetron Hydrochloride |
|
| prefixIRI |
Thesaurus:C48007 |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0700478 |
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| subClassOf |