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National Cancer Institute Thesaurus
| Preferred Name | Lidocaine Hydrochloride | |
| Synonyms |
2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide Monohydrochloride LIDOCAINE HYDROCHLORIDE Lidocaine Hydrochloride Xylocaine Xylocitin Xylotox |
|
| Definitions |
The hydrochloride salt form of lidocaine, an aminoethylamide and a prototypical member of the amide class anesthetics. Lidocaine interacts with voltage-gated Na+ channels in the nerve cell membrane and blocks the transient increase in permeability of excitable membranes to Na+. This prevents the generation and conduction of nerve impulses and produces a reversible loss of sensation. Lidocaine hydrochloride also exhibits class IB antiarrhythmic effects. The agent decreases the flow of sodium ions into myocardial tissue, especially on the Purkinje network, during phase 0 of the action potential, thereby decreasing depolarization, automaticity and excitability. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48000 |
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| CAS_Registry |
6108-05-0
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|
| CHEBI_ID |
CHEBI:60791
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| Chemical_Formula |
C14H22N2O.HCl.H2O
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|
| code |
C48000
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|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
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| Contributing_Source |
CTRP FDA
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|
| DEFINITION |
The hydrochloride salt form of lidocaine, an aminoethylamide and a prototypical member of the amide class anesthetics. Lidocaine interacts with voltage-gated Na+ channels in the nerve cell membrane and blocks the transient increase in permeability of excitable membranes to Na+. This prevents the generation and conduction of nerve impulses and produces a reversible loss of sensation. Lidocaine hydrochloride also exhibits class IB antiarrhythmic effects. The agent decreases the flow of sodium ions into myocardial tissue, especially on the Purkinje network, during phase 0 of the action potential, thereby decreasing depolarization, automaticity and excitability.
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|
| Display_Name |
Lidocaine Hydrochloride
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| FDA_UNII_Code |
V13007Z41A
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|
| FULL_SYN |
2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide Monohydrochloride LIDOCAINE HYDROCHLORIDE Lidocaine Hydrochloride Xylocaine Xylocitin Xylotox
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|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Lidocaine Hydrochloride
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|
| Legacy Concept Name |
Lidocaine_Hydrochloride
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| NCI_Drug_Dictionary_ID |
39607
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| PDQ_Closed_Trial_Search_ID |
39607
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| PDQ_Open_Trial_Search_ID |
39607
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|
| Preferred_Name |
Lidocaine Hydrochloride
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|
| prefixIRI |
Thesaurus:C48000
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|
| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0546869
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| subClassOf |
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