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National Cancer Institute Thesaurus
| Preferred Name | Fluphenazine Hydrochloride | |
| Synonyms |
Fluphenazine Hydrochloride FLUPHENAZINE HYDROCHLORIDE fluphenazine hydrochloride Permitil Prolixin |
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| Definitions |
The hydrochloride salt of fluphenazine, a phenothiazine with antipsychotic activity and potential antineoplastic activity. Fluphenazine blocks postsynaptic dopamine D2 receptors in the limbic system, cortical system and basal ganglia, resulting in a reduction of schizophrenia-associated hallucinations and delusions. In addition, as a serotonin antagonist, this agent may inhibit lymphocyte and myeloma cell proliferation by blocking 5-hydroxytrptamine type 1B (5-HT type 1B) receptors for serotonin. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47995 |
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| ALT_DEFINITION |
A drug that is used to treat mental and emotional disorders and is being studied in the treatment of multiple myeloma. Fluphenazine hydrochloride may stop tumor growth by keeping myeloma cells from dividing and causing them to die. It is a type of antipsychotic.
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| CAS_Registry |
146-56-5
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| Chemical_Formula |
C22H26F3N3OS.2HCl
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| code |
C47995
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
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| Contributing_Source |
CTRP FDA
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| DEFINITION |
The hydrochloride salt of fluphenazine, a phenothiazine with antipsychotic activity and potential antineoplastic activity. Fluphenazine blocks postsynaptic dopamine D2 receptors in the limbic system, cortical system and basal ganglia, resulting in a reduction of schizophrenia-associated hallucinations and delusions. In addition, as a serotonin antagonist, this agent may inhibit lymphocyte and myeloma cell proliferation by blocking 5-hydroxytrptamine type 1B (5-HT type 1B) receptors for serotonin.
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| Display_Name |
Fluphenazine Hydrochloride
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| FDA_UNII_Code |
ZOU145W1XL
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| FULL_SYN |
Fluphenazine Hydrochloride FLUPHENAZINE HYDROCHLORIDE fluphenazine hydrochloride Permitil Prolixin
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| Has_Free_Acid_Or_Base_Form | ||
| label |
Fluphenazine Hydrochloride
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| Legacy Concept Name |
Fluphenazine_Hydrochloride
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| NCI_Drug_Dictionary_ID |
487523
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| NSC Number |
179197
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| PDQ_Closed_Trial_Search_ID |
487523
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| PDQ_Open_Trial_Search_ID |
487523
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| Preferred_Name |
Fluphenazine Hydrochloride
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| prefixIRI |
Thesaurus:C47995
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0700567
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| subClassOf |
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