Link to this page
National Cancer Institute Thesaurus
| Preferred Name | Chlorhexidine Gluconate | |
| Synonyms |
Chlorhexidine Gluconate CHLORHEXIDINE GLUCONATE |
|
| Definitions |
The gluconate salt form of chlorhexidine, a biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine gluconate is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine gluconate penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47974 |
|
| CAS_Registry |
18472-51-0
|
|
| CHEBI_ID |
CHEBI:28312
|
|
| Chemical_Formula |
C22H30Cl2N10.2C6H12O7
|
|
| code |
C47974
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA
|
|
| DEFINITION |
The gluconate salt form of chlorhexidine, a biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine gluconate is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine gluconate penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent.
|
|
| Display_Name |
Chlorhexidine Gluconate
|
|
| FDA_UNII_Code |
MOR84MUD8E
|
|
| FULL_SYN |
Chlorhexidine Gluconate CHLORHEXIDINE GLUCONATE
|
|
| label |
Chlorhexidine Gluconate
|
|
| Legacy Concept Name |
Chlorhexidine_Gluconate
|
|
| NCI_Drug_Dictionary_ID |
747732
|
|
| PDQ_Closed_Trial_Search_ID |
747732
|
|
| PDQ_Open_Trial_Search_ID |
747732
|
|
| Preferred_Name |
Chlorhexidine Gluconate
|
|
| prefixIRI |
Thesaurus:C47974
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C0055361
|
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |