Link to this page
National Cancer Institute Thesaurus
| Preferred Name | Zolmitriptan | |
| Synonyms |
Zolmitriptan ZOLMITRIPTAN 2-Oxazolidinone, 4-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)methyl)-,(S)- 311C90 Zomig |
|
| Definitions |
A member of the triptan class of agents with anti-migraine properties. Zolmitriptan selectively binds to and activates serotonin (5-HT) 1B receptors expressed in intracranial arteries and 5-HT 1D receptors located on peripheral trigeminal sensory nerve terminals in the meninges and central terminals in brainstem sensory nuclei. Receptor binding results in constriction of cranial vessels, reduction of vessel pulsation and inhibition of nociceptive transmission, thereby providing relief of migraine headaches. Zolmitriptan may also relieve migraine headaches by inhibition of pro-inflammatory neuropeptide release. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47789 |
|
| CAS_Registry |
139264-17-8
|
|
| CHEBI_ID |
CHEBI:10124
|
|
| Chemical_Formula |
C16H21N3O2
|
|
| code |
C47789
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
|
|
| DEFINITION |
A member of the triptan class of agents with anti-migraine properties. Zolmitriptan selectively binds to and activates serotonin (5-HT) 1B receptors expressed in intracranial arteries and 5-HT 1D receptors located on peripheral trigeminal sensory nerve terminals in the meninges and central terminals in brainstem sensory nuclei. Receptor binding results in constriction of cranial vessels, reduction of vessel pulsation and inhibition of nociceptive transmission, thereby providing relief of migraine headaches. Zolmitriptan may also relieve migraine headaches by inhibition of pro-inflammatory neuropeptide release.
|
|
| FDA_UNII_Code |
2FS66TH3YW
|
|
| FULL_SYN |
Zolmitriptan ZOLMITRIPTAN 2-Oxazolidinone, 4-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)methyl)-,(S)- 311C90 Zomig
|
|
| label |
Zolmitriptan
|
|
| Legacy Concept Name |
Zolmitriptan
|
|
| NCI_Drug_Dictionary_ID |
779011
|
|
| PDQ_Closed_Trial_Search_ID |
779011
|
|
| PDQ_Open_Trial_Search_ID |
779011
|
|
| Preferred_Name |
Zolmitriptan
|
|
| prefixIRI |
Thesaurus:C47789
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C0528166
|
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |