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National Cancer Institute Thesaurus
| Preferred Name | Zanamivir | |
| Synonyms |
4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic Acid 5-Acetamido-2,6-anhydro-3,4,5-trideoxy-4-guanidino-D-glycero-D-galacto-non-2-enonic Acid GANA GG 167 Relenza ZANAMIVIR Zanamivir zanamivir |
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| Definitions |
A sialic acid-analogue neuraminidase inhibitor with antiviral activity. Administered into the respiratory tract by aerosol inhalation, zanamivir selectively binds to and inhibits influenza A and B virus neuraminidase-mediated cleavage of sialic acid residues in host cell membrane-bound glycoprotein receptors for influenza viruses, preventing the release of progeny viruses from host cell surfaces and, so, further viral replication. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47786 |
|
| ALT_DEFINITION |
A drug used to prevent and to treat influenza virus infections. It blocks the release of the virus from infected cells. It is a type of antiviral agent.
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| CAS_Registry |
139110-80-8
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| CHEBI_ID |
CHEBI:50663
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| Chemical_Formula |
C12H20N4O7
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|
| code |
C47786
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
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| Contributing_Source |
CTRP FDA
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| DEFINITION |
A sialic acid-analogue neuraminidase inhibitor with antiviral activity. Administered into the respiratory tract by aerosol inhalation, zanamivir selectively binds to and inhibits influenza A and B virus neuraminidase-mediated cleavage of sialic acid residues in host cell membrane-bound glycoprotein receptors for influenza viruses, preventing the release of progeny viruses from host cell surfaces and, so, further viral replication.
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| Display_Name |
Zanamivir
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|
| FDA_UNII_Code |
L6O3XI777I
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|
| FULL_SYN |
4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic Acid 5-Acetamido-2,6-anhydro-3,4,5-trideoxy-4-guanidino-D-glycero-D-galacto-non-2-enonic Acid GANA GG 167 Relenza ZANAMIVIR Zanamivir zanamivir
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|
| label |
Zanamivir
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|
| Legacy Concept Name |
Zanamivir
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| NCI_Drug_Dictionary_ID |
636195
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| PDQ_Closed_Trial_Search_ID |
636195
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| PDQ_Open_Trial_Search_ID |
636195
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|
| Preferred_Name |
Zanamivir
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|
| prefixIRI |
Thesaurus:C47786
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|
| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0216660
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| subClassOf |
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