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National Cancer Institute Thesaurus
| Preferred Name | Tirofiban Hydrochloride | |
| Synonyms |
Tirofiban Hydrochloride Monohydrate TIROFIBAN HYDROCHLORIDE Tirofiban Hydrochloride N-(Butylsulfonyl)-O-(4-(4-piperidinyl)butyl)-L-tyrosine Monohydrochloride Aggrastat MK 383 |
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| Definitions |
The hydrochloride salt form of tirofiban, a non-peptide tyrosine derivative with anticoagulant property. Tirofiban antagonizes fibrinogen binding to the platelet cell surface receptor, glycoprotein (GP) IIb/IIIA complex, one of the two purinergic receptors activated by ADP. The antagonism prevents adenylyl cyclase activation, which mediated via GP IIb/IIIa receptor complex, and results in decreased levels of cAMP and thereby interferes with platelet membrane function and subsequent platelet-platelet interaction, release of platelet granule constituents and prolongation of bleeding time. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47759 |
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| CAS_Registry |
150915-40-5
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| CHEBI_ID |
CHEBI:9606
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| Chemical_Formula |
C22H36N2O5S.HCl.H2O
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| code |
C47759
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| Concept_In_Subset | ||
| Contributing_Source |
FDA
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| DEFINITION |
The hydrochloride salt form of tirofiban, a non-peptide tyrosine derivative with anticoagulant property. Tirofiban antagonizes fibrinogen binding to the platelet cell surface receptor, glycoprotein (GP) IIb/IIIA complex, one of the two purinergic receptors activated by ADP. The antagonism prevents adenylyl cyclase activation, which mediated via GP IIb/IIIa receptor complex, and results in decreased levels of cAMP and thereby interferes with platelet membrane function and subsequent platelet-platelet interaction, release of platelet granule constituents and prolongation of bleeding time.
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| FDA_UNII_Code |
6H925F8O5J
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| FULL_SYN |
Tirofiban Hydrochloride Monohydrate TIROFIBAN HYDROCHLORIDE Tirofiban Hydrochloride N-(Butylsulfonyl)-O-(4-(4-piperidinyl)butyl)-L-tyrosine Monohydrochloride Aggrastat MK 383
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| Has_Free_Acid_Or_Base_Form | ||
| label |
Tirofiban Hydrochloride
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| Legacy Concept Name |
Tirofiban_Hydrochloride
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| Preferred_Name |
Tirofiban Hydrochloride
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| prefixIRI |
Thesaurus:C47759
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0795668
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| subClassOf |
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