National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Ticlopidine Hydrochloride

Synonyms

5-(o-Chlorobenzyl)-4,5,6,7-tetrahydrothieno(3,2-c)pyridinium Chloride

TICLOPIDINE HYDROCHLORIDE

Thieno(3,2-c)pyridine, 5-((2-chlorophenyl)methyl)-4,5,6,7-tetrahydro-, Hydrochloride

Ticlopidine Hydrochloride

Panaldine

Ticlid

Ticlodix

Ticlodone

Definitions

The hydrochloride salt form of ticlopidine, a thienopyridine derivative with anticoagulant property. Ticlopidine hydrochloride irreversibly inhibits adenosine-diphosphate (ADP)-induced platelet-fibrinogen binding by binding to the glycoprotein (GP) IIb/IIIA complex, one of the two purinergic receptors activated by ADP. Inhibition of the receptor activation causes the inhibition of adenylyl cyclase, results in decreased levels of cyclic adenosine monophosphate and thereby interferes with platelet membrane function and subsequent, platelet-platelet interaction, release of platelet granule constituents and prolongation of bleeding time.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47756

CAS_Registry

53885-35-1

CHEBI_ID

CHEBI:9589

Chemical_Formula

C14H14ClNS.HCl

code

C47756

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

The hydrochloride salt form of ticlopidine, a thienopyridine derivative with anticoagulant property. Ticlopidine hydrochloride irreversibly inhibits adenosine-diphosphate (ADP)-induced platelet-fibrinogen binding by binding to the glycoprotein (GP) IIb/IIIA complex, one of the two purinergic receptors activated by ADP. Inhibition of the receptor activation causes the inhibition of adenylyl cyclase, results in decreased levels of cyclic adenosine monophosphate and thereby interferes with platelet membrane function and subsequent, platelet-platelet interaction, release of platelet granule constituents and prolongation of bleeding time.

FDA_UNII_Code

A1L4914FMF

FULL_SYN

5-(o-Chlorobenzyl)-4,5,6,7-tetrahydrothieno(3,2-c)pyridinium Chloride

TICLOPIDINE HYDROCHLORIDE

Thieno(3,2-c)pyridine, 5-((2-chlorophenyl)methyl)-4,5,6,7-tetrahydro-, Hydrochloride

Ticlopidine Hydrochloride

Panaldine

Ticlid

Ticlodix

Ticlodone

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61972

label

Ticlopidine Hydrochloride

Legacy Concept Name

Ticlopidine_Hydrochloride

Preferred_Name

Ticlopidine Hydrochloride

prefixIRI

Thesaurus:C47756

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0000598

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80483

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