loading...| Preferred Name |
Thimerosal |
|
| Synonyms |
Merthiolate Sodium Mercury, ethyl(hydrogen o-mercaptobenzoato)-, Sodium Salt(8CI) Mercurate(1-), Ethyl(2-mercaptobenzoato(2-)-O,S)-, Sodium Ethyl(2-mercaptobenzoato-S)mercury, Sodium Salt ((o-Carboxyphenyl)thio)ethylmercury, Sodium Salt Ethylmercurithiosalicylate Sodium Sodium Ethylmercurithiosalicylate THIMEROSAL Thimerosal |
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| Definitions |
An organomercurial compound and derivative of thiosalicyclic acid with antibacterial and antifungal properties. Although the mechanism of action has not been fully elucidated, thimerosal inhibits sulfhydryl-containing active site of various enzymes and binds to sulfhydryl compounds, such as glutathione, cysteine, and SH groups of proteins. In addition, thimerosal activates the InsP3 calcium channel on endoplasmic reticular membrane, thereby triggering the release of calcium from intracellular stores resulting in a calcium-induced calcium-influx of extracellular calcium. Consequently, thimerosal may induce or inhibit cellular functions dependent on calcium signaling. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47751 |
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| CAS_Registry |
54-64-8 |
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| CHEBI_ID |
CHEBI:9546 |
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| Chemical_Formula |
C9H9HgO2S.Na |
|
| code |
C47751 |
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| Concept_In_Subset | ||
| Contributing_Source |
FDA |
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| DEFINITION |
An organomercurial compound and derivative of thiosalicyclic acid with antibacterial and antifungal properties. Although the mechanism of action has not been fully elucidated, thimerosal inhibits sulfhydryl-containing active site of various enzymes and binds to sulfhydryl compounds, such as glutathione, cysteine, and SH groups of proteins. In addition, thimerosal activates the InsP3 calcium channel on endoplasmic reticular membrane, thereby triggering the release of calcium from intracellular stores resulting in a calcium-induced calcium-influx of extracellular calcium. Consequently, thimerosal may induce or inhibit cellular functions dependent on calcium signaling. |
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| FDA_UNII_Code |
2225PI3MOV |
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| FULL_SYN |
Merthiolate Sodium Mercury, ethyl(hydrogen o-mercaptobenzoato)-, Sodium Salt(8CI) Mercurate(1-), Ethyl(2-mercaptobenzoato(2-)-O,S)-, Sodium Ethyl(2-mercaptobenzoato-S)mercury, Sodium Salt ((o-Carboxyphenyl)thio)ethylmercury, Sodium Salt Ethylmercurithiosalicylate Sodium Sodium Ethylmercurithiosalicylate THIMEROSAL Thimerosal |
|
| label |
Thimerosal |
|
| Legacy Concept Name |
Thimerosal |
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| NSC Number |
4794 |
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| Preferred_Name |
Thimerosal |
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| prefixIRI |
Thesaurus:C47751 |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0039867 |
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| subClassOf |