Link to this page
National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
Jump to:
| Preferred Name | Sertaconazole Nitrate | |
| Synonyms |
Sertaconazole Nitrate 1H-Imidazole, 1-(2-((7-chlorobenzo(b)thien-3-yl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-, Mononitrate SERTACONAZOLE NITRATE Dermofix Ertaczo Zalain |
|
| Definitions |
The nitrate salt form of sertaconazole, a synthetic imidazole derivative with antifungal property. Sertaconazole nitrate inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols and the inhibition of ergosterol synthesis, an essential component of the cell membrane of fungi. This leads to a disruption of cell membrane permeability and leakage of adenine triphosphate (ATP) and other constituents from fugal cells. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47716 |
|
| CAS_Registry |
99592-39-9
|
|
| Chemical_Formula |
C20H15Cl3N2OS.HNO3
|
|
| code |
C47716
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
|
|
| DEFINITION |
The nitrate salt form of sertaconazole, a synthetic imidazole derivative with antifungal property. Sertaconazole nitrate inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols and the inhibition of ergosterol synthesis, an essential component of the cell membrane of fungi. This leads to a disruption of cell membrane permeability and leakage of adenine triphosphate (ATP) and other constituents from fugal cells.
|
|
| FDA_UNII_Code |
1DV05410M5
|
|
| FULL_SYN |
Sertaconazole Nitrate 1H-Imidazole, 1-(2-((7-chlorobenzo(b)thien-3-yl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-, Mononitrate SERTACONAZOLE NITRATE Dermofix Ertaczo Zalain
|
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Sertaconazole Nitrate
|
|
| Legacy Concept Name |
Sertaconazole_Nitrate
|
|
| Preferred_Name |
Sertaconazole Nitrate
|
|
| prefixIRI |
Thesaurus:C47716
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C1528751
|
|
| subClassOf |
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |
Create mapping