National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Riluzole
Synonyms

2-Amino-6-(trifluoromethoxy)benzothiazole

RILUZOLE

Rilutek

Riluzole

riluzole

Definitions

A benzothiazole derivative with neuroprotective and potential anti-depressant and anxiolytic activities. While the mechanism of action of riluzole is unknown, its pharmacological activities in motor neurons include the following, some of which may be related to its effect: 1) an inhibitory effect on glutamate release, 2) inactivation of voltage-dependent sodium channels, and 3) interference with intracellular events that follow transmitter binding at excitatory amino acid receptors. In animal models, this agent has been shown to exhibit myorelaxant and sedative activities, apparently due to the blockade of glutamatergic neurotransmission.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47704

ALT_DEFINITION

A drug used to treat a nerve disease called amyotrophic lateral sclerosis (ALS). It is also being studied in the treatment of melanoma (a type of skin cancer). Riluzole blocks the release of a substance that melanoma cells need to grow. It is a type of glutamate release inhibitor.

CAS_Registry

1744-22-5

Chemical_Formula

C8H5F3N2OS

code

C47704

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

CTRP

FDA

DEFINITION

A benzothiazole derivative with neuroprotective and potential anti-depressant and anxiolytic activities. While the mechanism of action of riluzole is unknown, its pharmacological activities in motor neurons include the following, some of which may be related to its effect: 1) an inhibitory effect on glutamate release, 2) inactivation of voltage-dependent sodium channels, and 3) interference with intracellular events that follow transmitter binding at excitatory amino acid receptors. In animal models, this agent has been shown to exhibit myorelaxant and sedative activities, apparently due to the blockade of glutamatergic neurotransmission.

Display_Name

Riluzole

FDA_UNII_Code

7LJ087RS6F

FULL_SYN

2-Amino-6-(trifluoromethoxy)benzothiazole

RILUZOLE

Rilutek

Riluzole

riluzole

label

Riluzole

Legacy Concept Name

Riluzole

NCI_Drug_Dictionary_ID

594943

PDQ_Closed_Trial_Search_ID

594943

PDQ_Open_Trial_Search_ID

594943

Preferred_Name

Riluzole

prefixIRI

Thesaurus:C47704

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0073379

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C264

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Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_8863 DRON LOOM
http://www.co-ode.org/ontologies/galen#Riluzole GALEN LOOM
http://purl.obolibrary.org/obo/CHEBI_8863 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_8863 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_8863 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_8863 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_8863 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8863 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_8863 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_8863 TXPO LOOM
http://purl.obolibrary.org/obo/NCIT_C47704 BERO LOOM
http://purl.obolibrary.org/obo/OMIT_0019769 OMIT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0073379 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.675.651 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D019782 RH-MESH LOOM
https://go.drugbank.com/drugs/DB00740 MDM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386980005 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/dinto_DB00740 DINTO LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000594943 PDQ LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.129.708.089.611 RH-MESH LOOM
http://www.limics.fr/ontologies/ontoparonmed#Riluzole ONTOPARON LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#14761 OCHV LOOM
http://purl.bioontology.org/ontology/NDDF/005183 NDDF LOOM
http://purl.bioontology.org/ontology/RCD/dx1.. RCD LOOM
http://purl.bioontology.org/ontology/ATC/N07XX02 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.185.611 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148421 NDFRT LOOM
http://purl.bioontology.org/ontology/MESH/D019782 MESH LOOM
http://doe-generated-ontology.com/OntoAD#C0073379 ONTOAD LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017484 PMAPP-PMO LOOM
http://purl.obolibrary.org/obo/MESH_D019782 BERO LOOM
http://www.drugbank.ca/drugs/DB00740 FTC LOOM
http://purl.bioontology.org/ontology/RXNORM/35623 RXNORM LOOM
http://purl.bioontology.org/ontology/VANDF/4020941 VANDF LOOM
http://purl.jp/bio/4/id/200906056325945860 IOBC LOOM
http://stirdf.jst.go.jp/id/200907068098040572 IOBC LOOM