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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Quazepam | |
| Synonyms |
2H-1,4-Benzodiazepine-2-thione, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)- Doral Dormalin QUAZEPAM Quazepam Selepam |
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| Definitions |
A synthetic benzodiazepine derivative with anxiolytic, sedative and hypnotic properties. Quazepam and its major metabolite 2-oxoquazepam potentiate gamma-aminobutyric acid (GABA) activity by binding to the benzodiazepine-1 recognition site (BZ-1) within the GABA-A receptor, located in the limbic, neocortical and mesencephalic reticular system. This increases the frequency of GABA-activated chloride channel opening events, allowing the flow of chloride ions into the neuron leading to membrane hyperpolarization and decreased neuronal excitability. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47699 |
|
| CAS_Registry |
36735-22-5
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|
| Chemical_Formula |
C17H11ClF4N2S
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|
| code |
C47699
|
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| Concept_In_Subset | ||
| Contributing_Source |
FDA
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|
| DEFINITION |
A synthetic benzodiazepine derivative with anxiolytic, sedative and hypnotic properties. Quazepam and its major metabolite 2-oxoquazepam potentiate gamma-aminobutyric acid (GABA) activity by binding to the benzodiazepine-1 recognition site (BZ-1) within the GABA-A receptor, located in the limbic, neocortical and mesencephalic reticular system. This increases the frequency of GABA-activated chloride channel opening events, allowing the flow of chloride ions into the neuron leading to membrane hyperpolarization and decreased neuronal excitability.
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|
| FDA_UNII_Code |
JF8V0828ZI
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|
| FULL_SYN |
2H-1,4-Benzodiazepine-2-thione, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)- Doral Dormalin QUAZEPAM Quazepam Selepam
|
|
| label |
Quazepam
|
|
| Legacy Concept Name |
Quazepam
|
|
| NSC Number |
309702
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|
| Preferred_Name |
Quazepam
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|
| prefixIRI |
Thesaurus:C47699
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|
| Semantic_Type |
Pharmacologic Substance
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|
| UMLS_CUI |
C0072828
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| subClassOf |
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