National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Procaine Hydrochloride

Synonyms

Gerovital H3

Benzoic Acid, 4-amino-, 2-(diethylamino)ethyl Ester, Monohydrochloride

Procaine Hydrochloride

PROCAINE HYDROCHLORIDE

2-(Diethylamino)ethyl p-aminobenzoate Monohydrochloride

Allocaine

Novocain

Definitions

The hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47688

CAS_Registry

51-05-8

Chemical_Formula

C13H20N2O2.HCl

code

C47688

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

The hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation.

FDA_UNII_Code

95URV01IDQ

FULL_SYN

Gerovital H3

Benzoic Acid, 4-amino-, 2-(diethylamino)ethyl Ester, Monohydrochloride

Procaine Hydrochloride

PROCAINE HYDROCHLORIDE

2-(Diethylamino)ethyl p-aminobenzoate Monohydrochloride

Allocaine

Novocain

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61906

label

Procaine Hydrochloride

Legacy Concept Name

Procaine_Hydrochloride

NSC Number

169497

Preferred_Name

Procaine Hydrochloride

prefixIRI

Thesaurus:C47688

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0358490

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C245

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