loading...| Preferred Name |
Procainamide Hydrochloride |
|
| Synonyms |
PROCAINAMIDE HYDROCHLORIDE Pronestyl-SR Benzamide, 4-amino-N-(2-(diethylamino)ethyl)-, Monohydrochloride Procainamide Hydrochloride Novocamid Hydrochloride Procan SR Promine Pronestyl |
|
| Definitions |
The hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine. Procainamide hydrochloride reversibly binds to and blocks activated (open) voltage-gated sodium channels, thereby blocks the influx of sodium ions into the cell, which leads to an increase in threshold for excitation and inhibit depolarization during phase 0 of the action potential. In addition, the effective refractory period (ERP), action potential duration (APD), and ERP/APD ratios are increased, resulting in decreased impulse conduction velocity. The lasting action potential may also be due to blockage of outward K+ currents. The result is a decrease in automaticity, increase in refractory period and slowing of impulse conduction. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47687 |
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| CAS_Registry |
614-39-1 |
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| CHEBI_ID |
CHEBI:8429 |
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| Chemical_Formula |
C13H21N3O.HCl |
|
| code |
C47687 |
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| Concept_In_Subset | ||
| Contributing_Source |
FDA |
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| DEFINITION |
The hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine. Procainamide hydrochloride reversibly binds to and blocks activated (open) voltage-gated sodium channels, thereby blocks the influx of sodium ions into the cell, which leads to an increase in threshold for excitation and inhibit depolarization during phase 0 of the action potential. In addition, the effective refractory period (ERP), action potential duration (APD), and ERP/APD ratios are increased, resulting in decreased impulse conduction velocity. The lasting action potential may also be due to blockage of outward K+ currents. The result is a decrease in automaticity, increase in refractory period and slowing of impulse conduction. |
|
| FDA_UNII_Code |
SI4064O0LX |
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| FULL_SYN |
PROCAINAMIDE HYDROCHLORIDE Pronestyl-SR Benzamide, 4-amino-N-(2-(diethylamino)ethyl)-, Monohydrochloride Procainamide Hydrochloride Novocamid Hydrochloride Procan SR Promine Pronestyl |
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Procainamide Hydrochloride |
|
| Legacy Concept Name |
Procainamide_Hydrochloride |
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| NSC Number |
27461 |
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| Preferred_Name |
Procainamide Hydrochloride |
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| prefixIRI |
Thesaurus:C47687 |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0600311 |
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| subClassOf |