National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Pemirolast Potassium

Synonyms

Pemirolast Potassium

PEMIROLAST POTASSIUM

4H-Pyrido(1,2-a)pyrimidin-4-one, 9-methyl-3-(1H-tetrazol-5-yl)-, Potassium Salt

Alamast

Pemilaston

Definitions

The potassium salt form of pemirolast, a pyrimidinone derivative with antiallergic property. Pemirolast potassium exerts its action by blocking the antigen-mediated calcium ion influx into mast cells. This prevents mast cell degranulation, resulting in mast cell stabilization and inhibition of the release of inflammatory mediators, histamine and leukotrienes, which are involved in the allergic process. Pemirolast potassium also prevents inflammatory mediator release from eosinophils.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47654

CAS_Registry

100299-08-9

Chemical_Formula

C10H7N6O.K

code

C47654

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

The potassium salt form of pemirolast, a pyrimidinone derivative with antiallergic property. Pemirolast potassium exerts its action by blocking the antigen-mediated calcium ion influx into mast cells. This prevents mast cell degranulation, resulting in mast cell stabilization and inhibition of the release of inflammatory mediators, histamine and leukotrienes, which are involved in the allergic process. Pemirolast potassium also prevents inflammatory mediator release from eosinophils.

FDA_UNII_Code

497A17OUUE

FULL_SYN

Pemirolast Potassium

PEMIROLAST POTASSIUM

4H-Pyrido(1,2-a)pyrimidin-4-one, 9-methyl-3-(1H-tetrazol-5-yl)-, Potassium Salt

Alamast

Pemilaston

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66334

label

Pemirolast Potassium

Legacy Concept Name

Pemirolast_Potassium

Preferred_Name

Pemirolast Potassium

prefixIRI

Thesaurus:C47654

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0872971

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29714

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