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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Paromomycin Sulfate | |
| Synonyms |
D-Streptamine, O-2-amino-2-deoxy-alpha-D-glucopyranosyl-(1->4)-O-(O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1->3)-beta-D-ribofuranosyl-(1->5))-2-deoxy-, Sulfate(salt) Aminosidine Sulfate Paromomycin Sulfate Humycin sulfate PAROMOMYCIN SULFATE Humatin |
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| Definitions |
The sulfate salt form of paromomycin, a structural derivative of neomycin, an aminoglycoside antibiotic with amebicidal and bactericidal effects against predominantly aerobic gram-negative bacteria. Paromomycin binds specifically to the RNA oligonucleotide at the A site of bacterial 30S ribosomes, thereby causing misreading and premature termination of translation of mRNA and inhibition of protein synthesis followed by cell death. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47652 |
|
| CAS_Registry |
1263-89-4
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|
| CHEBI_ID |
CHEBI:7935
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|
| Chemical_Formula |
C23H45N5O14.H2SO4
|
|
| code |
C47652
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|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
|
|
| DEFINITION |
The sulfate salt form of paromomycin, a structural derivative of neomycin, an aminoglycoside antibiotic with amebicidal and bactericidal effects against predominantly aerobic gram-negative bacteria. Paromomycin binds specifically to the RNA oligonucleotide at the A site of bacterial 30S ribosomes, thereby causing misreading and premature termination of translation of mRNA and inhibition of protein synthesis followed by cell death.
|
|
| FDA_UNII_Code |
845NU6GJPS
|
|
| FULL_SYN |
D-Streptamine, O-2-amino-2-deoxy-alpha-D-glucopyranosyl-(1->4)-O-(O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1->3)-beta-D-ribofuranosyl-(1->5))-2-deoxy-, Sulfate(salt) Aminosidine Sulfate Paromomycin Sulfate Humycin sulfate PAROMOMYCIN SULFATE Humatin
|
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Paromomycin Sulfate
|
|
| Legacy Concept Name |
Paromomycin_Sulfate
|
|
| NCI_Drug_Dictionary_ID |
769609
|
|
| NSC Number |
227228
|
|
| PDQ_Closed_Trial_Search_ID |
769609
|
|
| PDQ_Open_Trial_Search_ID |
769609
|
|
| Preferred_Name |
Paromomycin Sulfate
|
|
| prefixIRI |
Thesaurus:C47652
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|
| Semantic_Type |
Pharmacologic Substance
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|
| UMLS_CUI |
C0205881
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|
| subClassOf |
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