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National Cancer Institute Thesaurus
| Preferred Name | Nedocromil Sodium | |
| Synonyms |
NEDOCROMIL SODIUM FPL 59002KP Nedocromil Sodium 4H-Pyrano[3,2-g]quinoline-2,8-dicarboxylic Acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-, Disodium Salt Alocril Tilade |
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| Definitions |
The sodium salt form of nedocromil, a pyranoquinolone derivative with anti-inflammatory properties. Nedocromil sodium inhibits the activation and release of inflammatory mediators (leukotrienes, histamine and prostaglandins) from a variety of cells involved in hypersensitivity reactions, including mast cells, eosinophils, neutrophils, macrophages, monocytes and platelets. As a result, nedocromil sodium inhibits both immediate and late bronchoconstriction, decreases bronchial hyperresponsiveness and inhibits recruitment of other inflammatory cells into the airway epithelium. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47635 |
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| CAS_Registry |
69049-74-7
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| CHEBI_ID |
CHEBI:7493
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| Chemical_Formula |
C19H15NO7.2Na
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| code |
C47635
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| Concept_In_Subset | ||
| Contributing_Source |
FDA
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| DEFINITION |
The sodium salt form of nedocromil, a pyranoquinolone derivative with anti-inflammatory properties. Nedocromil sodium inhibits the activation and release of inflammatory mediators (leukotrienes, histamine and prostaglandins) from a variety of cells involved in hypersensitivity reactions, including mast cells, eosinophils, neutrophils, macrophages, monocytes and platelets. As a result, nedocromil sodium inhibits both immediate and late bronchoconstriction, decreases bronchial hyperresponsiveness and inhibits recruitment of other inflammatory cells into the airway epithelium.
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| FDA_UNII_Code |
ET8IF4KS1T
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| FULL_SYN |
NEDOCROMIL SODIUM FPL 59002KP Nedocromil Sodium 4H-Pyrano[3,2-g]quinoline-2,8-dicarboxylic Acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-, Disodium Salt Alocril Tilade
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| Has_Free_Acid_Or_Base_Form | ||
| label |
Nedocromil Sodium
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| Legacy Concept Name |
Nedocromil_Sodium
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| Preferred_Name |
Nedocromil Sodium
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|
| prefixIRI |
Thesaurus:C47635
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0886658
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| subClassOf |
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