loading...| Preferred Name |
Midodrine Hydrochloride |
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| Synonyms |
ProAmantine Midodrine Hydrochloride 1-(2',5'-Dimethoxyphenyl)-2-glycinamidoethanol Hydrochloride (+-)-2-Amino-N-(beta-hydroxy-2,5-dimethoxyphenethyl)acetamide Monohydrochloride MIDODRINE HYDROCHLORIDE Amatine Gutron Midamine |
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| Definitions |
The hydrochloride salt form of midodrine, a direct-acting prodrug and sympathomimetic agent with antihypotensive properties. Midodrine is converted to its active metabolite, desglymidodrine by deglycination reaction. Desglymidodrine selectively binds to and activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This causes smooth muscle contraction and leads to an elevation of blood pressure. Desglymidodrine diffuses poorly across the blood-brain barrier, and is therefore not associated with effects on the central nervous system. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47620 |
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| CAS_Registry |
3092-17-9 43218-56-0 |
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| CHEBI_ID |
CHEBI:31847 |
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| Chemical_Formula |
C12H18N2O4.HCl |
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| code |
C47620 |
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| Concept_In_Subset | ||
| Contributing_Source |
FDA |
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| DEFINITION |
The hydrochloride salt form of midodrine, a direct-acting prodrug and sympathomimetic agent with antihypotensive properties. Midodrine is converted to its active metabolite, desglymidodrine by deglycination reaction. Desglymidodrine selectively binds to and activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This causes smooth muscle contraction and leads to an elevation of blood pressure. Desglymidodrine diffuses poorly across the blood-brain barrier, and is therefore not associated with effects on the central nervous system. |
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| FDA_UNII_Code |
59JV96YTXV |
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| FULL_SYN |
ProAmantine Midodrine Hydrochloride 1-(2',5'-Dimethoxyphenyl)-2-glycinamidoethanol Hydrochloride (+-)-2-Amino-N-(beta-hydroxy-2,5-dimethoxyphenethyl)acetamide Monohydrochloride MIDODRINE HYDROCHLORIDE Amatine Gutron Midamine |
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| Has_Free_Acid_Or_Base_Form | ||
| label |
Midodrine Hydrochloride |
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| Legacy Concept Name |
Midodrine_Hydrochloride |
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| Preferred_Name |
Midodrine Hydrochloride |
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| prefixIRI |
Thesaurus:C47620 |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0733394 |
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| subClassOf |