loading...| Preferred Name |
Loteprednol Etabonate |
|
| Synonyms |
LOTEPREDNOL ETABONATE Androsta-1,4-diene-17-carboxylic Acid, 17-((ethoxycarbonyl)oxy)-11-hydroxy-3-oxo-, chloromethyl Ester,(11beta,17alpha)- Loteprednol Etabonate Alrex Lotemax |
|
| Definitions |
The etabonate salt form of loteprednol, an ophthalmic analog of the corticosteroid prednisolone with anti-inflammatory activity. Loteprednol etabonate exerts its effect by interacting with specific intracellular receptors and subsequently binds to DNA to modify gene expression. This results in an induction of the synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. Loteprednol etabonate specifically induces phospholipase A2 inhibitory proteins (collectively called lipocortins), which inhibit the release of arachidonic acid, thereby inhibiting the biosynthesis of potent mediators of inflammation, such as prostaglandins and leukotrienes. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47589 |
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| CAS_Registry |
82034-46-6 |
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| CHEBI_ID |
CHEBI:31784 |
|
| Chemical_Formula |
C24H31ClO7 |
|
| code |
C47589 |
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| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
The etabonate salt form of loteprednol, an ophthalmic analog of the corticosteroid prednisolone with anti-inflammatory activity. Loteprednol etabonate exerts its effect by interacting with specific intracellular receptors and subsequently binds to DNA to modify gene expression. This results in an induction of the synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. Loteprednol etabonate specifically induces phospholipase A2 inhibitory proteins (collectively called lipocortins), which inhibit the release of arachidonic acid, thereby inhibiting the biosynthesis of potent mediators of inflammation, such as prostaglandins and leukotrienes. |
|
| FDA_UNII_Code |
YEH1EZ96K6 |
|
| FULL_SYN |
LOTEPREDNOL ETABONATE Androsta-1,4-diene-17-carboxylic Acid, 17-((ethoxycarbonyl)oxy)-11-hydroxy-3-oxo-, chloromethyl Ester,(11beta,17alpha)- Loteprednol Etabonate Alrex Lotemax |
|
| label |
Loteprednol Etabonate |
|
| Legacy Concept Name |
Loteprednol_Etabonate |
|
| Preferred_Name |
Loteprednol Etabonate |
|
| prefixIRI |
Thesaurus:C47589 |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0126177 |
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| subClassOf |