Link to this page
National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
Jump to:
| Preferred Name | Ketotifen Fumarate | |
| Synonyms |
4-(1-Methyl-4-piperidylidene)-4H-benzo[4,5]cyclohepta[1,2-b] thiophen-10(9H)-one hydrogen fumarate 10H-Benzo(4,5)cyclohepta(1,2-b)thiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-,(E)-2-butenedioate(1:1) KETOTIFEN FUMARATE Ketotifen Fumarate Zaditen Zaditor |
|
| Definitions |
The fumarate salt of ketotifen, a cycloheptathiophene derivative with anti-allergic activity. Ketotifen selectively blocks histamine (H1) receptors and prevents the typical symptoms caused by histamine release. This agent also interferes with the release of inflammatory mediators from mast cells involved in hypersensitivity reactions, thereby decreasing chemotaxis and activation of eosinophils. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47579 |
|
| CAS_Registry |
34580-14-8
|
|
| Chemical_Formula |
C19H19NOS.C4H4O4
|
|
| code |
C47579
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
|
|
| DEFINITION |
The fumarate salt of ketotifen, a cycloheptathiophene derivative with anti-allergic activity. Ketotifen selectively blocks histamine (H1) receptors and prevents the typical symptoms caused by histamine release. This agent also interferes with the release of inflammatory mediators from mast cells involved in hypersensitivity reactions, thereby decreasing chemotaxis and activation of eosinophils.
|
|
| FDA_UNII_Code |
HBD503WORO
|
|
| FULL_SYN |
4-(1-Methyl-4-piperidylidene)-4H-benzo[4,5]cyclohepta[1,2-b] thiophen-10(9H)-one hydrogen fumarate 10H-Benzo(4,5)cyclohepta(1,2-b)thiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-,(E)-2-butenedioate(1:1) KETOTIFEN FUMARATE Ketotifen Fumarate Zaditen Zaditor
|
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Ketotifen Fumarate
|
|
| Legacy Concept Name |
Ketotifen_Fumarate
|
|
| NCI_Drug_Dictionary_ID |
804026
|
|
| PDQ_Closed_Trial_Search_ID |
804026
|
|
| PDQ_Open_Trial_Search_ID |
804026
|
|
| Preferred_Name |
Ketotifen Fumarate
|
|
| prefixIRI |
Thesaurus:C47579
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C0043443
|
|
| subClassOf |
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |
Create mapping