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National Cancer Institute Thesaurus
| Preferred Name | Hydroxyzine Pamoate | |
| Synonyms |
HYDROXYZINE PAMOATE 2-(2-(4-(p-Chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)ethanol 4,4'-methylenebis(3-hydroxy-2-naphthoate) (1:1) Hydroxyzine Pamoate Ethanol, 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-, compound with 4,4'-Methylenebis(3-hydroxy-2-naphthalenecarboxylic Acid)(1:1) Atarax P Masmoran Paxistil Vistaril |
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| Definitions |
The pamoate salt form of hydroxyzine, a synthetic piperazine histamine H1-receptor antagonist with anti-allergic, antispasmodic, sedative, anti-emetic and anti-anxiety properties. Hydroxyzine pamoate blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial smooth muscle, and gastrointestinal smooth muscle, including vasodilatation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscle. In addition, hydroxyzine pamoate crosses the blood-brain barrier and acts on the histamine H1-receptors in the central nervous system. (NCI05) |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47560 |
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| CAS_Registry |
10246-75-0
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| CHEBI_ID |
CHEBI:31680
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| Chemical_Formula |
C23H16O6.C21H27ClN2O2
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| code |
C47560
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| Concept_In_Subset | ||
| Contributing_Source |
FDA
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| DEFINITION |
The pamoate salt form of hydroxyzine, a synthetic piperazine histamine H1-receptor antagonist with anti-allergic, antispasmodic, sedative, anti-emetic and anti-anxiety properties. Hydroxyzine pamoate blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial smooth muscle, and gastrointestinal smooth muscle, including vasodilatation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscle. In addition, hydroxyzine pamoate crosses the blood-brain barrier and acts on the histamine H1-receptors in the central nervous system. (NCI05)
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| FDA_UNII_Code |
M20215MUFR
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| FULL_SYN |
HYDROXYZINE PAMOATE 2-(2-(4-(p-Chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)ethanol 4,4'-methylenebis(3-hydroxy-2-naphthoate) (1:1) Hydroxyzine Pamoate Ethanol, 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-, compound with 4,4'-Methylenebis(3-hydroxy-2-naphthalenecarboxylic Acid)(1:1) Atarax P Masmoran Paxistil Vistaril
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| Has_Free_Acid_Or_Base_Form | ||
| label |
Hydroxyzine Pamoate
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| Legacy Concept Name |
Hydroxyzine_Pamoate
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| Preferred_Name |
Hydroxyzine Pamoate
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| prefixIRI |
Thesaurus:C47560
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0700539
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| subClassOf |
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