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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Guanfacine Hydrochloride | |
| Synonyms |
GUANFACINE HYDROCHLORIDE Guanfacine Hydrochloride N-(Aminoiminomethyl)-2,6-dichlorobenzeneacetamide Hydrochloride Estulic Tenex |
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| Definitions |
The hydrochloride salt form of guanfacine, a centrally acting alpha-2 adrenergic agonist with antihypertensive activity. Alpha-2 receptor stimulation by guanfacine hydrochloride results in a decreased sympathetic outflow from the vasomotor center to the heart, kidneys, and peripheral vasculature. This leads to a decrease in heart rate and peripheral vascular resistance. (NCI05) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47550 |
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| CAS_Registry |
29110-48-3
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|
| Chemical_Formula |
C9H9Cl2N3O.HCl
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|
| code |
C47550
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| Concept_In_Subset | ||
| Contributing_Source |
FDA
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| DEFINITION |
The hydrochloride salt form of guanfacine, a centrally acting alpha-2 adrenergic agonist with antihypertensive activity. Alpha-2 receptor stimulation by guanfacine hydrochloride results in a decreased sympathetic outflow from the vasomotor center to the heart, kidneys, and peripheral vasculature. This leads to a decrease in heart rate and peripheral vascular resistance. (NCI05)
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|
| FDA_UNII_Code |
PML56A160O
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| FULL_SYN |
GUANFACINE HYDROCHLORIDE Guanfacine Hydrochloride N-(Aminoiminomethyl)-2,6-dichlorobenzeneacetamide Hydrochloride Estulic Tenex
|
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Guanfacine Hydrochloride
|
|
| Legacy Concept Name |
Guanfacine_Hydrochloride
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| Preferred_Name |
Guanfacine Hydrochloride
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|
| prefixIRI |
Thesaurus:C47550
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0700472
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| subClassOf |
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