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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Eplerenone | |
| Synonyms |
9,11alpha-Epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid, gamma-lactone, Methyl Ester EPLERENONE Eplerenone Inspra |
|
| Definitions |
A selective aldosterone receptor antagonist. Eplerenone binds to the mineralocorticoid receptor and blocks the binding of aldosterone, thereby decreasing sodium resorption and subsequently increasing water outflow. This leads to a decrease in blood pressure. Eplerenone is used in the treatment of hypertension and congestive heart failure. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47513 |
|
| CAS_Registry |
107724-20-9
|
|
| CHEBI_ID |
CHEBI:31547
|
|
| Chemical_Formula |
C24H30O6
|
|
| code |
C47513
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
|
|
| DEFINITION |
A selective aldosterone receptor antagonist. Eplerenone binds to the mineralocorticoid receptor and blocks the binding of aldosterone, thereby decreasing sodium resorption and subsequently increasing water outflow. This leads to a decrease in blood pressure. Eplerenone is used in the treatment of hypertension and congestive heart failure.
|
|
| FDA_UNII_Code |
6995V82D0B
|
|
| FULL_SYN |
9,11alpha-Epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid, gamma-lactone, Methyl Ester EPLERENONE Eplerenone Inspra
|
|
| label |
Eplerenone
|
|
| Legacy Concept Name |
Eplerenone
|
|
| NCI_Drug_Dictionary_ID |
741940
|
|
| PDQ_Closed_Trial_Search_ID |
741940
|
|
| PDQ_Open_Trial_Search_ID |
741940
|
|
| Preferred_Name |
Eplerenone
|
|
| prefixIRI |
Thesaurus:C47513
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C0961485
|
|
| subClassOf |
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