National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Dipivefrin Hydrochloride
Synonyms

DIPIVEFRIN HYDROCHLORIDE

Dipivefrin Hydrochloride

(1)-4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-phenylene Dipivalate Hydrochloride

Propanoic Acid, 2,2-dimethyl-, 4-(1-hydroxy-2-(methylamino)ethyl)-1,2-phenylene Ester, Hydrochloride,(+-)-

Alcon

Propine

Definitions

An ester with sympathomimetic activities. Dipivefrin hydrochloride is a prodrug of epinephrine that, due to its greater lipophilicity, allows for better penetration into the anterior chamber. Once inside the eye, dipivefrin hydrochloride is converted by hydrolysis to epinephrine. Epinephrine enhances the outflow of aqueous humor and decreases the production of aqueous humor by vasoconstriction. This leads to a reduction in intraocular pressure.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47495

CAS_Registry

64019-93-8

CHEBI_ID

CHEBI:4647

Chemical_Formula

C19H29NO5.HCl

code

C47495

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

An ester with sympathomimetic activities. Dipivefrin hydrochloride is a prodrug of epinephrine that, due to its greater lipophilicity, allows for better penetration into the anterior chamber. Once inside the eye, dipivefrin hydrochloride is converted by hydrolysis to epinephrine. Epinephrine enhances the outflow of aqueous humor and decreases the production of aqueous humor by vasoconstriction. This leads to a reduction in intraocular pressure.

FDA_UNII_Code

5QTH9UHV0K

FULL_SYN

DIPIVEFRIN HYDROCHLORIDE

Dipivefrin Hydrochloride

(1)-4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-phenylene Dipivalate Hydrochloride

Propanoic Acid, 2,2-dimethyl-, 4-(1-hydroxy-2-(methylamino)ethyl)-1,2-phenylene Ester, Hydrochloride,(+-)-

Alcon

Propine

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61729

label

Dipivefrin Hydrochloride

Legacy Concept Name

Dipivefrin_Hydrochloride

Preferred_Name

Dipivefrin Hydrochloride

prefixIRI

Thesaurus:C47495

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0700488

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29705

Delete Subject Author Type Created
No notes to display