loading...| Preferred Name |
Difenoxin Hydrochloride |
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| Synonyms |
DIFENOXIN HYDROCHLORIDE Difenoxin Hydrochloride Isonipecotic Acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, Hydrochloride 4-Piperidinecarboxylic Acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, Monohydrochloride |
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| Definitions |
A phenylpiperidine with antidiarrheal activity and active metabolite of diphenoxylate. Difenoxin is chemically related to the narcotic opioid meperidine. Difenoxin hydrochloride acts primarily on the gastrointestinal wall by binding to opioid receptors on acetylcholine-containing nerves and inhibits the release of acetylcholine from presynaptic nerve terminals. This leads to a reduction in intestinal motility. Difenoxin hydrochloride also mimics the action of endogenous opioid peptides at the CNS opioid receptors, (primarily mu-receptors), thereby inducing CNS effects. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47487 |
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| CAS_Registry |
35607-36-4 |
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| CHEBI_ID |
CHEBI:59790 |
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| Chemical_Formula |
C28H28N2O2.HCl |
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| code |
C47487 |
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| Concept_In_Subset | ||
| Contributing_Source |
FDA |
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| DEFINITION |
A phenylpiperidine with antidiarrheal activity and active metabolite of diphenoxylate. Difenoxin is chemically related to the narcotic opioid meperidine. Difenoxin hydrochloride acts primarily on the gastrointestinal wall by binding to opioid receptors on acetylcholine-containing nerves and inhibits the release of acetylcholine from presynaptic nerve terminals. This leads to a reduction in intestinal motility. Difenoxin hydrochloride also mimics the action of endogenous opioid peptides at the CNS opioid receptors, (primarily mu-receptors), thereby inducing CNS effects. |
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| FDA_UNII_Code |
VQZ63K01IW |
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| FULL_SYN |
DIFENOXIN HYDROCHLORIDE Difenoxin Hydrochloride Isonipecotic Acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, Hydrochloride 4-Piperidinecarboxylic Acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, Monohydrochloride |
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| Has_Free_Acid_Or_Base_Form | ||
| label |
Difenoxin Hydrochloride |
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| Legacy Concept Name |
Difenoxin_Hydrochloride |
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| Preferred_Name |
Difenoxin Hydrochloride |
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| prefixIRI |
Thesaurus:C47487 |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0770333 |
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| subClassOf |