National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Dexmethylphenidate Hydrochloride
Synonyms

d-threo-Methylphenidate Hydrochloride

DEXMETHYLPHENIDATE HYDROCHLORIDE

2-Piperidineacetic Acid, Alpha-phenyl-, Methyl Ester, Hydrochloride, (alphaR,2R)-

Dexmethylphenidate Hydrochloride

Focalin

Definitions

A synthetic sympathomimetic amine with CNS stimulating properties. Dexmethylphenidate hydrochloride acts by facilitating the release of catecholamines, particularly noradrenaline and dopamine, from nerve terminals in the brain and inhibits their uptake. This leads to an increase in motor activity, causes euphoria, mental alertness and excitement and suppresses appetite. This drug causes dependence and may cause an increase in heart rate and blood pressure. It is used in the treatment of attention deficit hyperactivity disorder. It may also be used in the treatment of fatigue and other nervous system effects seen with chemotherapy.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47480

CAS_Registry

19262-68-1

Chemical_Formula

C14H19NO2.HCl

code

C47480

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A synthetic sympathomimetic amine with CNS stimulating properties. Dexmethylphenidate hydrochloride acts by facilitating the release of catecholamines, particularly noradrenaline and dopamine, from nerve terminals in the brain and inhibits their uptake. This leads to an increase in motor activity, causes euphoria, mental alertness and excitement and suppresses appetite. This drug causes dependence and may cause an increase in heart rate and blood pressure. It is used in the treatment of attention deficit hyperactivity disorder. It may also be used in the treatment of fatigue and other nervous system effects seen with chemotherapy.

FDA_UNII_Code

1678OK0E08

FULL_SYN

d-threo-Methylphenidate Hydrochloride

DEXMETHYLPHENIDATE HYDROCHLORIDE

2-Piperidineacetic Acid, Alpha-phenyl-, Methyl Ester, Hydrochloride, (alphaR,2R)-

Dexmethylphenidate Hydrochloride

Focalin

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26642

label

Dexmethylphenidate Hydrochloride

Legacy Concept Name

Dexmethylphenidate_Hydrochloride

Preferred_Name

Dexmethylphenidate Hydrochloride

prefixIRI

Thesaurus:C47480

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C1170743

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47795

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