National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Cysteamine Bitartrate

Synonyms

Cysteamine Bitartrate

CYSTEAMINE BITARTRATE

Cystagon

PROCYSBI

Definitions

An aminothiol salt used in the treatment of nephropathic cystinosis. Cysteamine bitartrate enters the cell and reacts with cystine producing cysteine and cysteine-cysteamine mixed disulfide compound, both of which, unlike cystine, can pass through the lysosomal membrane. This prevents the accumulation of cystine crystals in the lysosomes of patients with cystinosis, which can cause considerable damage and eventual destruction of the cells, particularly in the kidneys. (NCI05)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47467

CAS_Registry

27761-19-9

CHEBI_ID

CHEBI:50386

Chemical_Formula

C4H6O6.C2H7NS

code

C47467

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

An aminothiol salt used in the treatment of nephropathic cystinosis. Cysteamine bitartrate enters the cell and reacts with cystine producing cysteine and cysteine-cysteamine mixed disulfide compound, both of which, unlike cystine, can pass through the lysosomal membrane. This prevents the accumulation of cystine crystals in the lysosomes of patients with cystinosis, which can cause considerable damage and eventual destruction of the cells, particularly in the kidneys. (NCI05)

FDA_UNII_Code

QO84GZ3TST

FULL_SYN

Cysteamine Bitartrate

CYSTEAMINE BITARTRATE

Cystagon

PROCYSBI

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61696

label

Cysteamine Bitartrate

Legacy Concept Name

Cysteamine_Bitartrate

Preferred_Name

Cysteamine Bitartrate

prefixIRI

Thesaurus:C47467

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0282119

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29701

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