Link to this page
National Cancer Institute Thesaurus
| Preferred Name | Cloxacillin Sodium | |
| Synonyms |
Cloxacillin Sodium CLOXACILLIN SODIUM 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 6-(3-(2-chlorophenyl)-5-methyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-, Monosodium Salt,(2S,5R,6R)- 3-o-Chlorophenyl-5-methyl-4-isoxazolylpenicillin Sodium Cloxapen Orbenin Tegopen |
|
| Definitions |
The sodium salt of cloxaclliin, a semisynthetic beta-lactamase resistant penicillin antibiotic with antibacterial activity. Cloxacillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall, thereby preventing the cross-linkage of peptidoglycans, which are critical components of the bacterial cell wall. This leads to an interruption of the bacterial cell wall and causes bacterial cell lysis. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47460 |
|
| CAS_Registry |
7081-44-9
|
|
| CHEBI_ID |
CHEBI:34978
|
|
| Chemical_Formula |
C19H17ClN3O5S.Na.H2O
|
|
| code |
C47460
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
|
|
| DEFINITION |
The sodium salt of cloxaclliin, a semisynthetic beta-lactamase resistant penicillin antibiotic with antibacterial activity. Cloxacillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall, thereby preventing the cross-linkage of peptidoglycans, which are critical components of the bacterial cell wall. This leads to an interruption of the bacterial cell wall and causes bacterial cell lysis.
|
|
| FDA_UNII_Code |
65LCB00B4Y
|
|
| FULL_SYN |
Cloxacillin Sodium CLOXACILLIN SODIUM 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 6-(3-(2-chlorophenyl)-5-methyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-, Monosodium Salt,(2S,5R,6R)- 3-o-Chlorophenyl-5-methyl-4-isoxazolylpenicillin Sodium Cloxapen Orbenin Tegopen
|
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Cloxacillin Sodium
|
|
| Legacy Concept Name |
Cloxacillin_Sodium
|
|
| Preferred_Name |
Cloxacillin Sodium
|
|
| prefixIRI |
Thesaurus:C47460
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C0037496
|
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |