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National Cancer Institute Thesaurus
| Preferred Name | Clofazimine | |
| Synonyms |
2-Phenazinamine, 3,5-dihydro-N,5-bis(4-chlorophenyl)-3-((1-methylethyl)imino)- Clofazimine 3-(p-Chloranilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)-phenazine CLOFAZIMINE Lamprene |
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| Definitions |
A phenazine dye with anti-mycobacterial and anti-inflammatory activities. The exact mechanism through which clofazimine exerts its effect is unknown. However, it binds preferentially to mycobacterial DNA, thereby inhibiting DNA replication and cell growth. Clofazimine has a slow bactericidal effect on Mycobacterium leprae and is active against various other Mycobacteria. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47456 |
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| CAS_Registry |
2030-63-9
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| CHEBI_ID |
CHEBI:3749
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|
| code |
C47456
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
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| Contributing_Source |
CTRP FDA
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|
| DEFINITION |
A phenazine dye with anti-mycobacterial and anti-inflammatory activities. The exact mechanism through which clofazimine exerts its effect is unknown. However, it binds preferentially to mycobacterial DNA, thereby inhibiting DNA replication and cell growth. Clofazimine has a slow bactericidal effect on Mycobacterium leprae and is active against various other Mycobacteria.
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| Display_Name |
Clofazimine
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| FDA_UNII_Code |
D959AE5USF
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| FULL_SYN |
2-Phenazinamine, 3,5-dihydro-N,5-bis(4-chlorophenyl)-3-((1-methylethyl)imino)- Clofazimine 3-(p-Chloranilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)-phenazine CLOFAZIMINE Lamprene
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|
| label |
Clofazimine
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|
| Legacy Concept Name |
Clofazimine
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| NCI_Drug_Dictionary_ID |
811244
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| NSC Number |
141046
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| Preferred_Name |
Clofazimine
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| prefixIRI |
Thesaurus:C47456
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|
| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0008996
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| subClassOf |
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