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National Cancer Institute Thesaurus
| Preferred Name | Ceftizoxime Sodium | |
| Synonyms |
Ceftizoxime Sodium 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-(((2,3-dihydro-2-imino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxomonosodium Salt,(6R-(6alpha,7beta(Z)))- CEFTIZOXIME SODIUM Cefizox Epocelin |
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| Definitions |
The sodium salt form of ceftizoxime and a semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation cephalosporin antibiotic with bactericidal activity. Ceftizoxime sodium inhibits bacterial cell wall synthesis by inactivating penicillin binding proteins (PBPs) thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of the cell wall. Lack of cross-linking results in a reduction of cell wall stability and leads to cell lysis. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47438 |
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| CAS_Registry |
68401-82-1
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| CHEBI_ID |
CHEBI:3512
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| Chemical_Formula |
C13H12N5O5S2.Na
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| code |
C47438
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| Concept_In_Subset | ||
| Contributing_Source |
FDA
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| DEFINITION |
The sodium salt form of ceftizoxime and a semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation cephalosporin antibiotic with bactericidal activity. Ceftizoxime sodium inhibits bacterial cell wall synthesis by inactivating penicillin binding proteins (PBPs) thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of the cell wall. Lack of cross-linking results in a reduction of cell wall stability and leads to cell lysis.
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| FDA_UNII_Code |
26337D5X88
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| FULL_SYN |
Ceftizoxime Sodium 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-(((2,3-dihydro-2-imino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxomonosodium Salt,(6R-(6alpha,7beta(Z)))- CEFTIZOXIME SODIUM Cefizox Epocelin
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| Has_Free_Acid_Or_Base_Form | ||
| label |
Ceftizoxime Sodium
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| Legacy Concept Name |
Ceftizoxime_Sodium
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| Preferred_Name |
Ceftizoxime Sodium
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| prefixIRI |
Thesaurus:C47438
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0282391
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| subClassOf |
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