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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Butoconazole Nitrate | |
| Synonyms |
Butoconazole Nitrate (+-)-1-(4-(4-Chlorophenyl)-2-((2,6-dichlorophenyl)thio)butyl)-1H-imidazole Mononitrate BUTOCONAZOLE NITRATE Exelgyn Femstat Gynazole-1 Gynomyk Mycelex-3 RS-35887 |
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| Definitions |
The nitrate salt form of butaconazole, a synthetic imidazole derivative with fungistatic properties. Butoconazole nitrate interferes with steroid biosynthesis by inhibiting the conversion of lanosterol to ergosterol, thereby changing the fungal cell membrane lipid composition. This alters cell permeability and leads to growth inhibition. Butaconazole nitrate is active against many dermatophytes and yeasts. It also contains antibacterial effects against some gram-positive organisms. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47427 |
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| CAS_Registry |
64872-77-1
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|
| CHEBI_ID |
CHEBI:3241
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| Chemical_Formula |
C19H17Cl3N2S.HNO3
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|
| code |
C47427
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| Concept_In_Subset | ||
| Contributing_Source |
FDA
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| DEFINITION |
The nitrate salt form of butaconazole, a synthetic imidazole derivative with fungistatic properties. Butoconazole nitrate interferes with steroid biosynthesis by inhibiting the conversion of lanosterol to ergosterol, thereby changing the fungal cell membrane lipid composition. This alters cell permeability and leads to growth inhibition. Butaconazole nitrate is active against many dermatophytes and yeasts. It also contains antibacterial effects against some gram-positive organisms.
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| FDA_UNII_Code |
4805237NP5
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| FULL_SYN |
Butoconazole Nitrate (+-)-1-(4-(4-Chlorophenyl)-2-((2,6-dichlorophenyl)thio)butyl)-1H-imidazole Mononitrate BUTOCONAZOLE NITRATE Exelgyn Femstat Gynazole-1 Gynomyk Mycelex-3 RS-35887
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|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Butoconazole Nitrate
|
|
| Legacy Concept Name |
Butoconazole_Nitrate
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|
| Preferred_Name |
Butoconazole Nitrate
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|
| prefixIRI |
Thesaurus:C47427
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0107509
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| subClassOf |
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