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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Azelastine Hydrochloride | |
| Synonyms |
Azelastine Hydrochloride 1(2H)-Phthalazinone, 4-((4-Chlorophenyl)methyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-, Monohydrochloride AZELASTINE HYDROCHLORIDE Astelin Optivar W-2979M |
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| Definitions |
The hydrochloride salt form of azelastine, a phthalazinone derivative with antihistaminergic activity. Azelastine hydrochloride competes with histamine for the H1 receptor, thereby diminishing the actions of histamine on effector cells and decreasing the histamine-mediated symptoms of allergic reaction, such as bronchoconstriction, vasodilation, increased capillary permeability and spasmodic contractions of gastrointestinal smooth muscle. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47408 |
|
| Accepted_Therapeutic_Use_For |
seasonal allergic rhinitis
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|
| CAS_Registry |
79307-93-0
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|
| CHEBI_ID |
CHEBI:2951
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|
| Chemical_Formula |
C22H24ClN3O.HCl
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|
| code |
C47408
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| Concept_In_Subset | ||
| Contributing_Source |
FDA
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| DEFINITION |
The hydrochloride salt form of azelastine, a phthalazinone derivative with antihistaminergic activity. Azelastine hydrochloride competes with histamine for the H1 receptor, thereby diminishing the actions of histamine on effector cells and decreasing the histamine-mediated symptoms of allergic reaction, such as bronchoconstriction, vasodilation, increased capillary permeability and spasmodic contractions of gastrointestinal smooth muscle.
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|
| FDA_UNII_Code |
0L591QR10I
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|
| FULL_SYN |
Azelastine Hydrochloride 1(2H)-Phthalazinone, 4-((4-Chlorophenyl)methyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-, Monohydrochloride AZELASTINE HYDROCHLORIDE Astelin Optivar W-2979M
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|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Azelastine Hydrochloride
|
|
| Legacy Concept Name |
Azelastine_Hydrochloride
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|
| Preferred_Name |
Azelastine Hydrochloride
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|
| prefixIRI |
Thesaurus:C47408
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|
| Semantic_Type |
Pharmacologic Substance
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|
| UMLS_CUI |
C0771004
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|
| subClassOf |
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