loading...| Preferred Name |
Apomorphine Hydrochloride |
|
| Synonyms |
4H-Dibenzo(de,g)quinoline-10,11-diol, 5,6,6a,7-Tetrahydro-6-methyl-, Hydrochloride,(6aR)- N-Methylnorapomorphine Hydrochloride APOMORPHINE HYDROCHLORIDE Apomorphine Hydrochloride 6ab-Aporphine-10,11-diol Hydrochloride Hemihydrate Apokyn Uprima |
|
| Definitions |
The hydrochloride salt form of apomorphine, a derivative of morphine and non-ergoline dopamine agonist with high selectivity for dopamine D2, D3, D4 and D5 receptors. Apomorphine hydrochloride acts by stimulating dopamine receptors in the nigrostriatal system, hypothalamus, limbic system, pituitary gland, and blood vessels. This enhances motor function, suppresses prolactin release, and causes vasodilation and behavioral effects. Apomorphine hydrochloride is used in the treatment of Parkinson's disease and erectile dysfunction. In addition, apomorphine hydrochloride acts on the chemoreceptor trigger zone and is used as a central emetic in the treatment of drug overdose. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47400 |
|
| CAS_Registry |
41372-20-7 |
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| CHEBI_ID |
CHEBI:31228 |
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| Chemical_Formula |
2C17H17NO2.2ClH.H2O |
|
| code |
C47400 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
The hydrochloride salt form of apomorphine, a derivative of morphine and non-ergoline dopamine agonist with high selectivity for dopamine D2, D3, D4 and D5 receptors. Apomorphine hydrochloride acts by stimulating dopamine receptors in the nigrostriatal system, hypothalamus, limbic system, pituitary gland, and blood vessels. This enhances motor function, suppresses prolactin release, and causes vasodilation and behavioral effects. Apomorphine hydrochloride is used in the treatment of Parkinson's disease and erectile dysfunction. In addition, apomorphine hydrochloride acts on the chemoreceptor trigger zone and is used as a central emetic in the treatment of drug overdose. |
|
| FDA_UNII_Code |
F39049Y068 |
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| FULL_SYN |
4H-Dibenzo(de,g)quinoline-10,11-diol, 5,6,6a,7-Tetrahydro-6-methyl-, Hydrochloride,(6aR)- N-Methylnorapomorphine Hydrochloride APOMORPHINE HYDROCHLORIDE Apomorphine Hydrochloride 6ab-Aporphine-10,11-diol Hydrochloride Hemihydrate Apokyn Uprima |
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| Has_Free_Acid_Or_Base_Form | ||
| label |
Apomorphine Hydrochloride |
|
| Legacy Concept Name |
Apomorphine_Hydrochloride |
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| NSC Number |
11442 |
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| Preferred_Name |
Apomorphine Hydrochloride |
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| prefixIRI |
Thesaurus:C47400 |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0237406 |
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| subClassOf |